Subjects' expectations in neuroimaging research
Subjects' expectations in neuroimaging research
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DOI：
10.1002/jmri.20499
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发表时间：
2006-02-01
影响因子：
4.4
通讯作者：
Illes, J
中科院分区：
文献类型：
--
作者：
Kirschen, MP;Jaworska, A;Illes, J
目的：探讨受试者对神经影像研究中偶然发现的检测和处理的态度和期望。材料和方法：对105名曾在医疗和非医疗环境中参与神经激怒研究的健康对照受试者进行调查，了解他们对研究脑部扫描中意外临床发现的期望和态度。我们假设，即使参与者同意扫描程序仅用于研究目的，他们仍然希望病理检查(如果存在)被发现并报告给他们。结果：54%的参与者报告说，他们希望研究扫描可以发现异常情况。几乎所有的受试者(90%)都报告说他们希望将研究结果传达给他们，许多人(59%)更喜欢由隶属于研究团队的医生完成这项工作。无论他们是在医疗或非医疗环境下接受扫描，参与者的反应都是相似的。结论：在获得书面和口头知情同意时，明确处理偶然发现的程序对于确保受试者的期望与研究的目的和范围一致至关重要。
Purpose: To explore subjects' attitudes and expectations concerning the detection and management of incidental findings in neuroimaging research.Materials and Methods: Healthy control subjects (N = 105) who previously participated in neuroinraging studies in medical and nonmedical settings were surveyed about their expectations and attitudes toward unexpected clinical findings on their research brain scans. We hypothesized that even though the participants consented to a scanning procedure for research purposes alone, they would still expect pathology, if present, to be detected and reported to them.Results: Fifty-four percent of participants reported that they expected research scans to detect abnormalities if they existed. Nearly all subjects (> 90%) reported that they would want findings communicated to them, and many (59%) preferred this to be done by a physician affiliated with the research team. The participants responded in similar ways whether they were scanned in medical or nonmedical settings.Conclusion: Clarity about procedures for handling incidental findings when obtaining written and verbal informed consent is essential to ensure that the subjects' expectations are consistent with the purpose and scope of the research.