17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior.
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior.
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DOI：
10.1111/acel.12703
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发表时间：
2018-03
期刊：
影响因子：
7.8
通讯作者：
Stout MB
中科院分区：
文献类型：
--
作者：
Steyn FJ;Ngo ST;Chen VP;Bailey-Downs LC;Xie TY;Ghadami M;Brimijoin S;Freeman WM;Rubinstein M;Low MJ;Stout MB
减肥是减轻肥胖老年人疾病负担的有效干预措施。减少食物摄入从而促进体重减轻的药物干预可能是减少年龄相关疾病的有效策略。我们之前报道过17α‐雌二醇（17α‐E2）对老年雄性小鼠的代谢和炎症有有益的影响。这些观察结果与减少卡路里摄入有关。在这里，我们证明了17α‐E2通过弓形核（ARC）中的前阿片黑素皮质素（Pomc）表达来减少肥胖小鼠模型的食物摄入量和体重。这些结果证实，17α‐E2通过下丘脑厌食通路中的选择性相互作用调节食欲。有趣的是，在ARC Pomc转录几乎完全丧失的动物中，代谢稳态的一些外周标志物也得到了改善。这表明17α‐E2可能具有中枢和外周作用，可以协同或独立地有益地影响代谢。
Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age‐related disease. We previously reported that 17α‐estradiol (17α‐E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α‐E2 acts through pro‐opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α‐E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α‐E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.
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影响因子：
7.8
作者：
Harrison DE;Strong R;Allison DB;Ames BN;Astle CM;Atamna H;Fernandez E;Flurkey K;Javors MA;Nadon NL;Nelson JF;Pletcher S;Simpkins JW;Smith D;Wilkinson JE;Miller RA
通讯作者：
Miller RA
影响因子：
5.3
作者：
Zhan, Cheng;Zhou, Jingfeng;Luo, Minmin
通讯作者：
Luo, Minmin
17α-雌二醇减轻雄性小鼠年龄相关的代谢和炎症功能障碍，而不会诱导女性化。
DOI：
10.1093/gerona/glv309
发表时间：
2017-01
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Stout MB;Steyn FJ;Jurczak MJ;Camporez JG;Zhu Y;Hawse JR;Jurk D;Palmer AK;Xu M;Pirtskhalava T;Evans GL;de Souza Santos R;Frank AP;White TA;Monroe DG;Singh RJ;Casaclang-Verzosa G;Miller JD;Clegg DJ;LeBrasseur NK;von Zglinicki T;Shulman GI;Tchkonia T;Kirkland JL
通讯作者：
Kirkland JL
影响因子：
4.5
作者：
Lam DD;de Souza FS;Nasif S;Yamashita M;López-Leal R;Otero-Corchon V;Meece K;Sampath H;Mercer AJ;Wardlaw SL;Rubinstein M;Low MJ
通讯作者：
Low MJ
影响因子：
3.9
作者：
Waters, Debra L.;Ward, Aimee L.;Villareal, Dennis T.
通讯作者：
Villareal, Dennis T.