Genetic polymorphisms of the endocannabinoid system in obesity and diabetes
Genetic polymorphisms of the endocannabinoid system in obesity and diabetes
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DOI：
10.1111/dom.13504
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发表时间：
2019-02-01
影响因子：
5.8
通讯作者：
O'Sullivan, Saoirse E.
中科院分区：
文献类型：
--
作者：
Doris, Joseph M.;Millar, Sophie A.;O'Sullivan, Saoirse E.
内源性大麻素系统（ECS）参与许多生理过程，包括生育、疼痛和能量调节。本系统综述的目的是检查 ECS 的单核苷酸多态性 (SNP) 对肥胖和葡萄糖代谢的贡献。数据库检索发现 734 篇文章，其中 65 篇被纳入；这些涵盖了编码大麻素受体1和2（CB1、CB2）、脂肪酸酰胺水解酶（FAAH）和N-酰基磷脂酰乙醇胺磷脂酶D（NAPE-PLD）的基因中的70个SNP。没有研究包括与单酰基甘油脂肪酶或二酰基甘油脂肪酶相关的 SNP。 CB1 受体 SNP rs1049353 显示与较低体重指数 (BMI) 和脂肪量有 17 种关联（五项研究）。它还显示出与较低胰岛素水平的三种关联（一项研究）。相反，CB1 受体 SNP rs806368 与 BMI 和腰围增加相关（两项研究）。 FAAH SNP rs324420 与肥胖增加相关（三项研究）。 NAPE-PLD 的单倍型与 BMI 降低相关（一项研究）。总共 60 个 SNP 与任何测量结果均没有关联。本综述表明 ECS SNP 在能量和葡萄糖代谢中发挥着复杂但重要的作用。
The endocannabinoid system (ECS) is involved in many physiological processes including fertility, pain and energy regulation. The aim of this systematic review was to examine the contribution of single nucleotide polymorphisms (SNPs) of the ECS to adiposity and glucose metabolism. Database searches identified 734 articles, of which 65 were included; these covered 70 SNPs in genes coding for cannabinoid receptors 1 and 2 (CB1, CB2), fatty acid amide hydrolase (FAAH) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD). No studies included SNPs relating to monoacylglycerol lipase or diacylglycerol lipase. The CB1 receptor SNP rs1049353 showed 17 associations with lower body mass index (BMI) and fat mass (five studies). It also showed three associations with lower insulin levels (one study). Conversely, the CB1 receptor SNP rs806368 was associated with increased BMI and waist circumference (two studies). The FAAH SNP rs324420 was associated with increased obesity (three studies). A haplotype of NAPE-PLD was associated with decreased BMI (one study). A total of 60 SNPs showed no association with any measured outcome. This review suggests a complex but important role of ECS SNPs in energy and glucose metabolism.