Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma
Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma
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DOI：
10.1016/j.anl.2010.10.009
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发表时间：
2011-08-01
影响因子：
1.7
通讯作者：
Kawano, Kenji
中科院分区：
文献类型：
--
作者：
Ikeda, Katsuhisa;Yokoi, Hidenori;Kawano, Kenji
目的：已知哮喘的合作率导致构件后鼻窦手术的预后不佳（ess后）。细菌感染可能在鼻窦炎的复发性病理生理学中起关键作用。方法：42例与经历ESS的哮喘有关的CRS患者。在急性传染性发作时，从鼻窦腔进行了细菌培养。根据类固醇的反应性和峰值呼气流（PEF）分析了鼻纳纳纳拉纳索病的复发。分析：在ess后，完全获得了75名抽吸物；来自10例患者的2个重复抽吸，5例患者和2例患者的4例。从5例（11.9％）获得的6个标本（8.0％）仅显示出生长，而从69个样本中回收了83种分离株。 16例患者至少有16例PEF大幅下降的所有患者，除了一名患者抱怨症状和上呼吸道感染的迹象，在PEF阳性抑郁症之前，在急性加重时检查了11例PEF阳性培养的症状。 CRS.Conconconcution：细菌感染可能在后随访期间复发性息肉和难治性症状起关键作用。此外，疾病恶化伴随着哮喘加重。 （c）2010年Elsevier Ireland Ltd.保留所有权利。
Objectives: Co-mobidity of asthma is known to result in a poor prognosis of post-endoscopic sinus surgery (post-ESS). Bacterial infection may play a key role in recurrent pathophysiology of sinusitis in post-ESS.Methods: Forty-two patients with CRS associated with asthma undergoing ESS were enrolled. Bacterial culture was performed from the sinus cavity at the time of acute infectious episodes. Recurrence of sinonasal disease was analyzed in terms of steroid responsiveness and peak expiratory flow(PEF).Results: Totally 75 aspirates were obtained during post-ESS; 2 repeat aspirates from 10 patients, 3 from 5 patients, and 4 from 2 patients. Only 6 specimens (8.0%) obtained from 5 patients (11.9%) showed no growth whereas 83 isolates were recovered from 69 specimens. Sixteen patients had at least one episode of a significant decline of PEF All except one patient complained of symptoms and signs of upper respiratory infections prior to a depression of PEF Positive culture was obtained in 10 out of 11 patients examined at the time of acute exacerbation of CRS.Conclusion: Bacterial infection may play a critical role of recurrent polyps and refractory symptoms during post-ESS follow-up. Moreover, worsening of sinusitis accompanies asthma exacerbation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.