Laser stereolithography and supercritical fluid processing or custom-designed implant fabrication
Laser stereolithography and supercritical fluid processing or custom-designed implant fabrication
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DOI：
10.1023/b:jmsm.0000011812.08185.2a
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发表时间：
2004-02-01
影响因子：
3.7
通讯作者：
Howdle, SM
中科院分区：
文献类型：
--
作者：
Popov, VK;Evseev, AV;Howdle, SM
本文介绍了用激光光聚合的方法制备聚官能团丙烯酸单体、光引发剂和羟基磷灰石（HA）的液体混合物。基于三维计算机建模得到的图像，采用激光立体光刻技术制备了具有特定形状和结构的纯聚合物和复合材料。然后用超临界二氧化碳处理聚合物，以去除潜在的有毒残留物（单体、低分子量低聚物等），并提供相互连接的微孔隙。最后，将样品植入大鼠（股骨舒张期骨骺），研究活组织反应及骨整合和骨诱导过程。研究表明，将透明质酸掺入复合种植体结构可促进骨膜和骨膜内成骨，特别是改善其骨整合特性。超临界二氧化碳处理显著增强了材料的生物相容性，增加了种植体表面与再生骨组织的直接接触面积。(C) 2004 Kluwer学术出版社。
This paper describes the laser photopolymerization of a liquid mixture of polyfunctional acrylic monomers, photoinitiator and hydroxyapatite (HA). Pure polymeric and composite materials of specific shape and structure were fabricated by laser stereolithography based on images derived from three-dimensional (3D) computer modeling. The polymeric objects then were treated with supercritical carbon dioxide to remove potentially toxic residues (monomers, low molecular weight oligomers, etc.) and to provide interconnective microporosity. Finally, samples were implanted into white rats (diastolic epiphysis of femoral bone) to study living tissue response and processes of osteointegration and osteoinduction. It was shown that incorporation of HA into the composite implant structure encouraged periosteal as well as endosteal osteogenesis and improved their osteointegrative characteristics in particular. Supercritical carbon dioxide treatment significantly enhanced the biocompatibility of the materials, increasing the area of direct contact of the implant surface with regenerated bone tissue. (C) 2004 Kluwer Academic Publishers.