Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification
Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification
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DOI：
10.1016/j.bbrc.2007.12.019
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发表时间：
2008-02-22
影响因子：
3.1
通讯作者：
Yoshikawa, Toshikazu
中科院分区：
文献类型：
--
作者：
Aoi, Wataru;Naito, Yuji;Yoshikawa, Toshikazu
细胞内氧化还原平衡可能影响骨骼肌的营养代谢。虾青素是一种存在于多种天然食物中的类胡萝卜素，在骨骼肌中具有很高的抗氧化能力。本研究旨在探讨虾青素对运动中肌肉脂代谢的影响。将8周龄ICR小鼠分为四组：久坐组、久坐加虾青素组、跑步运动组和运动加虾青素组。治疗4周后，运动组进行跑步机跑步。与正常饮食的小鼠相比，虾青素在运动中增加了脂肪的利用，并延长了运动到精疲力竭的时间。虾青素增加了脂肪酸转位酶与肉碱棕榈酰转移酶I(CPT I)在骨骼肌中的共定位。我们还发现，运动增加了CPT I的己酰-赖氨酸修饰，而虾青素则阻止了这种增加。在另外的实验中，我们发现虾青素治疗加速了运动训练中体内脂肪积累的减少。结果提示，虾青素通过激活CPT I促进运动过程中的脂肪代谢，而不是葡萄糖的利用，从而提高耐力，有效地减少运动后脂肪组织。(C)2007 Elsevier Inc.保留所有权利。
Intracellular redox balance may affect nutrient metabolism in skeletal muscle. Astaxanthin, a carotenoid contained in various natural foods, exerts hi h antioxidative capacity in the skeletal muscles. The present study investigated the effect of astaxanthin on muscle lipid metabolism in exercise. ICR mice (8 weeks old) were divided into four different groups: sedentary, sedentary treated with astaxanthin, running exercise, and exercise treated with astaxanthin. After 4 weeks of treatment, exercise groups performed treadmill running. Asiaxanthin increased fat utilization during exercise compared with mice on a normal diet with prolongation of the running time to exhaustion. Colocalization of fatty acid translocase with carnitine palmitoyltransferase I (CPT I) in skeletal muscle was increased by astaxanthin. We also found that hexanoyl-lysine modification of CPT I was increased by exercise, while astaxanthin prevented this increase. In additional experiment, we found that astaxanthin treatment accelerated the decrease of body fat accumulation with exercise training. Our results suggested that astaxanthin promoted lipid metabolism rather than glucose utilization during exercise via CPT I activation, which led to improvement of endurance and efficient reduction of adipose tissue with training. (c) 2007 Elsevier Inc. All rights reserved.