Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR αβ lymphocytes
Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR αβ lymphocytes
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DOI：
10.1002/eji.200425210
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发表时间：
2004-12-01
影响因子：
5.4
通讯作者：
Roosnek, E
中科院分区：
文献类型：
--
作者：
Arlettaz, L;Villard, J;Roosnek, E
CD8(+) T 细胞亚群表达自然杀伤细胞受体 CD94:NKG2A 或 CD94:NKG2C。我们发现，尽管许多CD8+T细胞转录CD94和NKG2C，但功能性CD94:NKG2C受体的表达仅限于高度分化的效应细胞。 CD94:NKG2A 由 CCR7(+) 记忆细胞和 CCR7(-) 效应细胞组成的不同子集表达。由于 NKG2A 只能在初始 CD8+ T 细胞上诱导，而 CD94- 记忆细胞难以诱导，因此很可能在第一次遇到抗原时就发生了对 CD94:NKG2A(+) 亚群的承诺。 CCR7(+)CD94:NKG2A(+) T 细胞通过淋巴结再循环，激活后产生大量 IFN-γ。这些细胞作为独立的 CD94:NKG2A(+) T 细胞谱系出现，具有与原位激活的其他 CD8(+)CD94(-) T 细胞不同的独特 TCR 库。
A subset of CD8(+) T cells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8(+) T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a different subset consisting of CCR7(+) memory cells and CCR7(-) effector cells. Since NKG2A can only be induced on naive CD8(+) T cells while CD94(-) memory cells are refractory, it is likely that commitment to the CD94:NKG2A(+) subset occurs during the first encounter with antigen. CCR7(+)CD94:NKG2A(+) T cells recirculate through lymph nodes where upon activation, they produce large quantities of IFN-gamma. These cells occur as a separate CD94:NKG2A(+) T cell lineage with a distinct TCR repertoire that differs from that of the other CD8(+)CD94(-) T cells activated in situ.