UvA-DARE (Digital Academic Repository) Neural systems for social cognition in Klinefelter syndrome (47,XXY): evidence from fMRI
UvA-DARE (Digital Academic Repository) Neural systems for social cognition in Klinefelter syndrome (47,XXY): evidence from fMRI
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UvA-DARE（数字学术知识库）克兰费尔特综合征社会认知的神经系统 (47,XXY)：来自功能磁共振成像的证据
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通讯作者：
André Aleman
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作者：
S. Rijn;H. Swaab;D. Baas;Edward H.F. de Haan;René S. Kahn;André Aleman
克兰费尔特综合征（KS）是一种染色体疾病（47，XXY），可能有助于我们解开基因-大脑行为途径的精神病理学。该表型包括社会认知障碍和自闭症特征风险增加。我们使用功能性MRI来研究社会信息处理的神经机制。18名非临床对照和13名XXY男性在判断面部可信度和年龄时进行了扫描。在判断面孔是否值得信任时，XXY男性在以下方面的激活程度低于对照组：（i）杏仁核，它在筛选社会情感意义的信息中起着关键作用;（ii）杏仁核，它在主观情感体验中起着重要作用;以及（iii）梭状回和（iv）上级颞沟，这两个都涉及到面部的知觉处理，也较少涉及到XXY男性的年龄判断。这是第一项研究表明，KS可以与减少参与的神经网络subserving社会认知。研究KS可能会增加我们对神经功能障碍的遗传和激素基础的理解，这些神经功能障碍导致社会认知和行为异常，这些异常被认为是自闭症和精神分裂症等精神疾病的核心异常。
Klinefelter syndrome (KS) is a chromosomal condition (47, XXY) that may help us to unravel gene – brain behavior pathways to psychopathology. The phenotype includes social cognitive impairments and increased risk for autism traits. We used functional MRI to study neural mechanisms underlying social information processing. Eighteen nonclinical controls and thirteen men with XXY were scanned during judgments of faces with regard to trustworthiness and age. While judging faces as untrustworthy in comparison to trustworthy, men with XXY displayed less activation than controls in (i) the amygdala, which plays a key role in screening information for socio-emotional significance, (ii) the insula, which plays a role in subjective emotional experience, as well as (iii) the fusiform gyrus and (iv) the superior temporal sulcus, which are both involved in the perceptual processing of faces and which were also less involved during age judgments in men with XXY. This is the first study showing that KS can be associated with reduced involvement of the neural network subserving social cognition. Studying KS may increase our understanding of the genetic and hormonal basis of neural dysfunctions contributing to abnormalities in social cognition and behavior, which are considered core abnormalities in psychiatric disorders such as autism and schizophrenia.
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作者：
Visootsak, Jeannie;Graham, John M., Jr.
通讯作者：
Graham, John M., Jr.