Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone
Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone
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DOI：
10.1073/pnas.94.14.7537
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发表时间：
1997-07-08
影响因子：
11.1
通讯作者：
Roberts, E
中科院分区：
文献类型：
--
作者：
Morley, JE;Kaiser, F;Roberts, E
对56名年龄在20 ~ 84岁之间的异常健康男性进行了横断面调查。测量了选定的类固醇成分和血清中的肽类激素，并进行了认知和身体测试。在这些与年龄呈高度显著负相关（r > -0.6）的血清变量中，生物可利用睾酮（BT）、硫酸脱氢表雄酮（DHEAS）和胰岛素样生长因子1（IGF-1）与生长激素（GH）的比值显示出与年龄相关的变化的阶梯模式，最接近于年龄阶梯本身。其中，BT与年龄相关的认知和身体指标相关性最好。由于DHEAS与BT相关性很好，而与认知和身体指标的相关性比BT差得多，因此BT和/或BT在组织中产生的物质似乎在所测量功能的限速过程中发挥更直接的作用，而DHEAS与这些功能的关系更为间接。IGF-1/GH与年龄的高度相关性，与BT的相关性相对较低，以及IGF-1/GH和BT与年龄显着相关的认知和身体指标的相关模式表明GH-IGF-1轴和BT在影响这些功能方面发挥独立作用。口服后的一系列测定和文献数据表明，类固醇代谢系统与GH-IGF-1轴中控制相互关系的操作系统之间存在相互依赖性。同时纵向测量血清BT，DHEAS和IGF-1/GH水平，并详细研究其与年龄相关的功能指标的相关性，可能有助于检测早期年龄相关的失调，并可能有助于设计改善方法。
A cross sectional survey was made in 56 exceptionally healthy males, ranging in age from 20 to 84 years. Measurements were made of selected steroidal components and peptidic hormones in blood serum, and cognitive and physical tests were performed. Of those blood serum variables that gave highly significant negative correlations with age (r > -0.6), bioavailable testosterone (BT), dehydroepiandrosterone sulfate (DHEAS), and the ratio of insulin-like growth factor 1 (IGF-1) to growth hormone (GH) showed a stepwise pattern of age-related changes most closely resembling those of the age steps themselves. Of these, BT correlated best with significantly age correlated cognitive and physical measures. Because DHEAS correlated well with BT and considerably less well than BT with the cognitive and physical measures, it seems likely that BT and/or substances to which BT gives rise in tissues play a more direct role in whatever processes are rate-limiting in the functions measured and that DHEAS relates more indirectly to these functions. The high correlation of IGF-1/GH with age, its relatively low correlation with BT, and the patterns of correlations of IGF-1/GH and BT with significantly age-correlated cognitive and physical measures suggest that the GH-IGF-1 axis and BT play independent roles in affecting these functions. Serial determinations made after oral ingestion of pregnenolone and data from the literature suggest there is interdependence of steroid metabolic systems with those operational in control of interrelations in the GH-IGF-1 axis. Longitudinal concurrent measurements of serum levels of BT, DHEAS, and IGF-1/GH together with detailed studies of their correlations with age-correlated functional measures may be useful in detecting early age-related dysregulations and may be helpful in devising ameliorative approaches.