Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
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DOI：
10.1038/mp.2012.107
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发表时间：
2013-08-01
影响因子：
11
通讯作者：
Martins, R. N.
中科院分区：
文献类型：
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作者：
Brown, B. M.;Peiffer, J. J.;Martins, R. N.
以前的研究表明，体育活动可以提高认知能力，降低阿尔茨海默病（AD）的风险。然而，被认为受身体活动影响的关键AD致病因素，特别是血浆淀粉样蛋白β（A β）和A β脑负荷，尚未得到彻底研究。本研究的目的是确定血浆Ab和淀粉样蛋白脑沉积是否与体力活动水平相关，以及载脂蛋白E（APOE）β 4等位基因携带者和非携带者之间的相关性是否不同。这些分析包括来自澳大利亚成像，生物标志物和生活方式老龄化研究（Aibl）的546名认知完整的参与者（年龄60-95岁）。使用国际体力活动问卷（IPAQ）测量习惯性体力活动水平。在空腹血液样本中测量血清胰岛素、葡萄糖、胆固醇和血浆A β水平。一个亚组（n = 116）进行C-11-匹兹堡化合物B（Pi B）正电子发射断层扫描（PET），以定量脑淀粉样蛋白负荷。高水平的体力活动与高密度脂蛋白（HDL）（P = 0.037）和低胰岛素（P
Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to be influenced by physical activity, particularly plasma amyloid-beta (A beta) and A beta brain load, have yet to be thoroughly investigated. The objective of this study was to determine if plasma Ab and amyloid brain deposition are associated with physical activity levels, and whether these associations differed between carriers and non-carriers of the apolipoprotein E (APOE) epsilon 4 allele. Five-hundred and forty six cognitively intact participants (aged 60-95 years) from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) were included in these analyses. Habitual physical activity levels were measured using the International Physical Activity Questionnaire (IPAQ). Serum insulin, glucose, cholesterol and plasma A beta levels were measured in fasting blood samples. A subgroup (n = 116) underwent C-11-Pittsburgh compound B (PiB) positron emission tomography (PET) scanning to quantify brain amyloid load. Higher levels of physical activity were associated with higher high density lipoprotein (HDL) (P = 0.037), and lower insulin (P