Sinoaortic denervation in the nonhuman primate.
Sinoaortic denervation in the nonhuman primate.
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非人类灵长类动物的主动脉去神经支配。
DOI：
10.1152/ajpregu.1987.252.2.r294
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Hamm,C
中科院分区：
文献类型：
--
作者：
Bishop,VS;Shade,RE;Haywood,JR;Hamm,C
对于通过窦主动脉去传入去除压力感受器输入是否会导致四足动物持续的高血压，有相当大的争议。由于压力感受器反射在姿势变化中的重要性，压力感受器去神经在灵长类动物中的影响可能更加深远。在这项研究中，6只成年雄性狒狒(Papio Anubis)被维持在系绳系统上，以观察主动脉以及联合颈动脉窦和主动脉压力感受器去传入的急性和持续性影响。平均动脉压(MAP)由86+/-4.0升至105+/-5.5 mm Hg。去窦弓神经传入后1周，动脉压升至129±12.9 mm Hg，4周后降至97±4.4 mm Hg。动脉压的不稳定性(以24小时以上标准差的平均值测量)不随去主动脉神经而改变，但在压力感受器完全去神经后1周和4周时增加。这些研究表明，压力感受器在灵长类动物中的去传入导致动脉压、动脉压不稳定和心率的急剧增加。而失神经后4wk，动脉压水平和不稳定性有所下降，但仍显著升高。
There is considerable controversy as to whether removal of baroreceptor input by sinoaortic deafferentation leads to a sustained hypertension in quadripeds. Because of the importance of the baroreflex during postural changes, the effects of baroreceptor denervation may be even more profound in the primate. In this study, six adult male baboons (Papio anubis) were maintained on a tether system to examine the acute and sustained effects of aortic and combined carotid sinus and aortic baroreceptor deafferentation. Mean arterial pressure (MAP) averaged over 24 h increased from 86 +/- 4.0 to 105 +/- 5.5 mmHg after aortic denervation. One week after sinoaortic deafferentation, arterial pressure rose to 129 +/- 12.9 mmHg and then receded to 97 +/- 4.4 mmHg at 4 wk postdenervation. The lability of arterial pressure (measured as the mean of the standard deviations over 24 h) did not change with aortic denervation but increased at 1 and 4 wk after complete baroreceptor denervation. These studies indicate that baroreceptor deafferentation in the primate results in an acute increase in arterial pressure, the lability of arterial pressure, and heart rate. However, by 4 wk postdenervation, the level and lability of arterial pressure are decreased but remain significantly elevated.