RELATIONSHIP BETWEEN INFECTIVITY AND OSPC EXPRESSION IN LYME-DISEASE BORRELIA
RELATIONSHIP BETWEEN INFECTIVITY AND OSPC EXPRESSION IN LYME-DISEASE BORRELIA
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DOI：
10.1111/j.1574-6968.1994.tb07242.x
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发表时间：
1994-11-01
影响因子：
2.1
通讯作者：
YANAGIHARA, Y
中科院分区：
文献类型：
--
作者：
MASUZAWA, T;KURITA, T;YANAGIHARA, Y
Borrelia burgdorferi sensu stricto strain 297 and B. garinii strains HP1 and 12-92 were serially subcultured for 36-50 passages in vitro for 1 year. All low-passage strains showed abundant expression of outer surface protein C (OspC) in the 22-23-kDa range, but the high-passage strains lost or showed reduced expression of OspC in comparison with the low-passage strains. The low-passage strains efficiently infected outbred ddY mice when inoculated into the hind footpad or peritoneal cavity. In contrast, the incidence of infection with the high-passage strains was low. Isolates from the bladders of mice inoculated with the high-passage strains expressed large amounts of OspC in comparison with those originally inoculated. These results indicate that OspC expression is related to the infectivity of Lyme disease borreliae.
