The reaction mechanism of nitrosothiols with copper(I)
The reaction mechanism of nitrosothiols with copper(I)
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DOI：
10.1007/s007750050365
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发表时间：
2000-04-01
影响因子：
3
通讯作者：
Meyerstein, D
中科院分区：
文献类型：
--
作者：
Burg, A;Cohen, H;Meyerstein, D
铜和其他过渡金属离子及其络合物是分解亚硝基硫醇的催化剂。本文报道了两种亚硝基硫醇S-亚硝基硫代乳酸和S-亚硝基谷胱甘肽（GSNO）与铜（I）的反应动力学和机理。研究了Cu（MeCN）（n）（+）（n=0-3）与亚硝基硫醇的反应动力学。结果表明，Cu-aq（+）是GSNO体系的活性物种，其k（Cu-aq（+）+GSNO）=（9.4+/-2.0）× 10（7）dm（3）mol（-1）s（-1）. Cu（MeCN）（n）（+）+（n=0-3）配合物与S-亚硝基硫代乳酸反应。在这些过程中形成了过渡物种。结果表明，这些化合物中含有铜（I）和巯基，这为铜配合物在S-亚硝基硫醇分解反应中的催化作用提供了新的线索。
Copper and other transition metal ions and their complexes are catalysts for the decomposition of nitrosothiols. In this way they catalyze the biological functions of nitrosothiols, The kinetics and mechanism of the reaction of two nitrosothiols, S-nitrosothiolactic acid and S-nitrosoglutathione (GSNO), with copper(I) are reported. The kinetics of the reaction of Cu(MeCN)(n)(+) (n=0-3) with the nitrosothiols were studied. The results indicate that Cu-aq(+) is the active species in the GSNO system, with k(Cu-aq(+)+GSNO)=(9.4+/-2.0) x 10(7) dm(3) mol(-1) s(-1). The results also indicate that the Cu(MeCN)(n)(+)+ (n=0-3) complexes react with S-nitrosothiolactic acid. Transient species are formed in these processes. The results suggest that these species contain copper(I) and thiol, The results shed light on the catalytic role of copper complexes in the decomposition of S-nitrosothiols.