Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury.
Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury.
复制标题
创伤性脑损伤后患者的失配消极性、社会认知和功能结果
DOI：
10.4103/1673-5374.155437
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发表时间：
2015-04
影响因子：
6.1
通讯作者：
Tao LY
中科院分区：
文献类型：
--
作者：
Sun HY;Li Q;Chen XP;Tao LY
错配负波自动生成，是脑损伤患者神经元完整性受损和功能异常导致认知功能下降的早期监测指标。抗精神病药物不能影响失配负性。本研究旨在探讨脑损伤后失匹配负波与神经认知、日常生活和社会功能的关系。本研究招募了12名创伤性脑损伤患者和12名健康对照者。我们用韦氏成人智力量表中国修订版检查神经认知，用日常生活能力量表和社会功能筛查量表分别检查日常和社会功能结果。从脑电图记录中分析不匹配负波。结果表明，与健康对照组相比，创伤性脑损伤患者的失匹配负波幅度降低。失匹配负波振幅与创伤性脑损伤后患者的神经认知测量值呈负相关，与功能结局呈正相关。此外，最显着的正相关性之间的不匹配负额中央区域和功能结果的措施。FCz电极的负性失配与日常生活功能之间也存在最显著的正相关。在脑损伤患者中，不匹配的负波幅度与Fz电极的社会残疾筛查计划评分呈极显著正相关。这些实验结果表明，失配负波可能有效地反映创伤性脑损伤后患者的功能结果。
Mismatch negativity is generated automatically, and is an early monitoring indicator of neuronal integrity impairment and functional abnormality in patients with brain injury, leading to decline of cognitive function. Antipsychotic medication cannot affect mismatch negativity. The present study aimed to explore the relationships of mismatch negativity with neurocognition, daily life and social functional outcomes in patients after brain injury. Twelve patients with traumatic brain injury and 12 healthy controls were recruited in this study. We examined neurocognition with the Wechsler Adult Intelligence Scale-Revised China, and daily and social functional outcomes with the Activity of Daily Living Scale and Social Disability Screening Schedule, respectively. Mismatch negativity was analyzed from electroencephalogram recording. The results showed that mismatch negativity amplitudes decreased in patients with traumatic brain injury compared with healthy controls. Mismatch negativity amplitude was negatively correlated with measurements of neurocognition and positively correlated with functional outcomes in patients after traumatic brain injury. Further, the most significant positive correlations were found between mismatch negativity in the fronto-central region and measures of functional outcomes. The most significant positive correlations were also found between mismatch negativity at the FCz electrode and daily living function. Mismatch negativity amplitudes were extremely positively associated with Social Disability Screening Schedule scores at the Fz electrode in brain injury patients. These experimental findings suggest that mismatch negativity might efficiently reflect functional outcomes in patients after traumatic brain injury.