Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer
Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer
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DOI：
10.1002/jso.20329
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发表时间：
2005-09-01
影响因子：
2.5
通讯作者：
Keeling, NJ
中科院分区：
文献类型：
--
作者：
Walsh, SR;Cook, EJ;Keeling, NJ
背景和目的：需要简单的方法来识别有复发风险的结直肠癌患者。本研究旨在确定嗜中性粒细胞与淋巴细胞比率（NLR）是否预测结直肠癌patients.Methods的生存率：230例诊断为结直肠癌患者在两年的时间内被确定为前瞻性维护结直肠癌数据库。根据术前全血细胞计数计算NLR。对于未接受手术的患者，使用其门诊访视的全血细胞计数。记录已知的预后因素。总体和癌症特异性survival.Results：术前NLR大于5相关的总体和癌症特异性生存在单变量分析。NLR不是独立的Dukes stage.Conclusions：术前NLR可能是一种简单的方法，确定结直肠癌患者术前预后不良。
Background and Objectives: Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil-to-lymphocyte ratio (NLR) predicts survival in colorectal cancer patients.Methods: Two-hundred thirty patients diagnosed with colorectal cancer over a two-year period were identified from a prospectively maintained colorectal cancer database. NLR was calculated from pre-operative full blood counts. In the case of patients who did not undergo surgery, the full blood count from their out-patient visit was used. Known prognostic factors were recorded. Overall and cancer-specific survival were calculated.Results: Pre-operative NLR greater than 5 correlated with overall and cancer-specific survival in univariate analyses. NLR was not independent of Dukes stage.Conclusions: Pre-operative NLR may represent a simple method of identifying colorectal cancer patients with a poor prognosis pre-operatively.