Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction.

Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction.
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发表时间：
2000-11
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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通讯作者：
C. Meltzer;M. Cantwell;Phil J. Greer;D. Ben-Eliezer;G. Smith;G. Frank;W. Kaye;P. Houck;J. Price
C. Meltzer;M. Cantwell;Phil J. Greer;D. Ben-Eliezer;G. Smith;G. Frank;W. Kaye;P. Houck;J. Price
中科院分区：
其他
文献类型：
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作者：
C. Meltzer;M. Cantwell;Phil J. Greer;D. Ben-Eliezer;G. Smith;G. Frank;W. Kaye;P. Houck;J. Price

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关于脑灌注是否随着健康老龄化而下降仍然是一个有争议的问题。PET体内成像可以定量评估大脑生理学;然而，之前的PET研究并不一致地报告了脑血流量（CBF）、氧代谢和葡萄糖代谢的衰老减少。在某种程度上，这可能是因为缺乏校正的稀释效应的年龄相关的脑容量损失的PET测量。方法使用[15 O]H2O对27名健康个体（年龄范围，19-76岁）进行CBF PET扫描，并使用基于MR的算法校正脑萎缩的部分容积效应。结果在校正部分容积效应之前，年轻/中年（年龄范围，19-46岁;平均值+/- SD，56+/-10 mL/100 mL/min）和老年（年龄范围，60-76岁;平均值+/- SD，49+/-2.6 mL/100 mL/min）亚组之间的平均皮质CBF存在显著差异（P = 0.01）。然而，在部分容量校正后，这一组差异消失（年轻/中年：平均值+/- SD，62+/-10 mL/100 mL/min;老年：平均值+/- SD，61+/-4.8 mL/100 mL/min; P = 0.66）。当考虑所有受试者时，年龄和皮质CBF测量值之间存在轻度但显著的负相关性，但未校正的数据不存在。结论：本研究表明，健康个体的CBF可能不会随着年龄的增长而下降，并且未能纠正年龄相关性脑萎缩的稀释效应可能会混淆先前PET研究的解释，这些研究表明生理测量值会随着年龄的增长而减少。
UNLABELLED It remains a matter of controversy as to whether cerebral perfusion declines with healthy aging. In vivo imaging with PET permits quantitative evaluation of brain physiology; however, previous PET studies have inconsistently reported aging reductions in cerebral blood flow (CBF), oxygen metabolism, and glucose metabolism. In part, this may be because of a lack of correction for the dilution effect of age-related cerebral volume loss on PET measurements. METHODS CBF PET scans were obtained using [15O]H2O in 27 healthy individuals (age range, 19-76 y) and corrected for partial-volume effects from cerebral atrophy using an MR-based algorithm. RESULTS There was a significant difference (P = 0.01) in mean cortical CBF between young/midlife (age range, 19-46 y; mean +/- SD, 56+/-10 mL/100 mL/min) and elderly (age range, 60-76 y; mean +/- SD, 49+/-2.6 mL/100 mL/min) subgroups before correcting for partial-volume effects. However, this group difference resolved after partial-volume correction (young/midlife: mean +/- SD, 62+/-10 mL/100 mL/min; elderly: mean +/- SD, 61+/-4.8 mL/100 mL/min; P = 0.66). When all subjects were considered, a mild but significant inverse correlation between age and cortical CBF measurements was present in the uncorrected but not the corrected data. CONCLUSION This study suggests that CBF may not decline with age in healthy individuals and that failure to correct for the dilution effect of age-related cerebral atrophy may confound interpretation of previous PET studies that have shown aging reductions in physiologic measurements.