Decreased corpus callosum size among alcoholic women
Decreased corpus callosum size among alcoholic women
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DOI：
10.1001/archneur.1996.00550040099019
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发表时间：
1996-04-01
影响因子：
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通讯作者：
Eckardt, M
中科院分区：
文献类型：
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作者：
Hommer, D;Momenan, R;Eckardt, M
背景：尽管女性似乎对酒精中毒对肝脏的影响更敏感，但目前尚不清楚女性是否比男性对过量饮酒对大脑的影响更敏感。研究对象和方法：我们比较了14名住院的酗酒女性和13名住院的酗酒男性与9名非酗酒女性和10名非酗酒男性的胼胝体横截面积。所有受试者年龄在30至50岁之间。在正中矢状面t -1加权磁共振图像上测量胼胝体和颅骨内表的横截面积。结果：女性颅内面积小于男性，但酗酒者与非酗酒者颅内面积无差异。酗酒妇女的胼胝体面积明显小于两组。控制组的女人和酗酒的男人。酗酒者与对照组在胼胝体区域没有差异。当通过协方差分析调整胼胝体面积为颅内面积时，这些结果没有改变。当胼胝体被分成四个等长的部分时，面积的减少并不局限于任何特定的区域。结论：这些结果表明，与酗酒男性相比，酗酒女性对酒精引起的脑损伤的敏感性更高。
Background: Although females appear to be more sensitive to the hepatic consequences of alcoholism, it is not clear if women are more sensitive to the effects of excessive alcohol consumption on the brain than men.Subjects and Methods: We compared the cross-sectional area of the corpus callosum in a group of 14 hospitalized alcoholic women and 13 hospitalized alcoholic men with a group of nine nonalcoholic women and 10 nonalcoholic men. All subjects were between the ages of 30 and 50 years. The cross-sectional areas of the corpus callosum and the inner table of the skull were measured on midsagittal T-1-weighted magnetic resonance images.Results: Females had smaller intracranial areas than males, but there was no difference in intracranial area between the alcoholics and nonalcoholics. The corpus callosum area was significantly smaller among the alcoholic women compared with either. the control women or the alcoholic men. Alcoholic men did not differ from control men in the corpus callosum area. These results did not change when the corpus callosum area was adjusted for intracranial area by analysis of covariance. When the corpus callosum was divided into four segments of equal length, the reduction in area was not localized to any particular region.Conclusion: These results suggest an increased sensitivity to alcohol-induced brain damage among alcoholic women compared with alcoholic men.