FcγRIIB, FcγRIIIB, and systemic lupus erythematosus
FcγRIIB, FcγRIIIB, and systemic lupus erythematosus
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DOI：
10.1111/j.1749-6632.2009.05132.x
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Smith, Kenneth G. C.
中科院分区：
文献类型：
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作者：
Niederer, Heather A.;Clatworthy, Menna R.;Smith, Kenneth G. C.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特征是免疫复合物在肾脏等器官中的沉积。这是多种免疫学异常的结果，包括高水平自身抗体的产生和免疫复合物的失调处理。IgG的Fc部分的受体关键地参与免疫复合物处理和清除以及B细胞活化的调节。低亲和力Fc γ受体的多态性与许多自身免疫性疾病（包括SLE）的易感性相关。我们回顾了两个这样的受体在狼疮发病机制中的作用-抑制性受体Fc γ RIIB和糖基磷脂酰肌醇连接的激活性受体Fc γ RIIIB。最近的工作增强了我们对Fc γ RIIB 1232 T多态性的作用机制以及该受体在SLE中的总体作用的理解。人中性粒细胞抗原-1同种异型Fc γ RIIIB和受体在SLE中的作用进行了讨论，关于最近确定的FCGR 3B的拷贝数变异和低拷贝数与SLE的关联。
The autoimmune disease systemic lupus erythematosus (SLE) is characterized by the deposition of immune complexes in organs such as the kidney. This Occurs as a result of multiple immunological abnormalities, including the production of high levels of autoantibody and dysregulated handling of immune complexes. Receptors for the Fc portion of IgG are critically involved in immune complex handling and clearance and in the regulation of B-cell activation. Polymorphisms in the low-affinity Fc gamma receptors have been associated with susceptibility to a number of autoimmune diseases, including SLE. We review the role of two such receptors in the pathogenesis of lupus-the inhibitory receptor Fc gamma RIIB and the glycosylphosphatidylinositol-linked activatory receptor Fc gamma RIIIB. Recent work has enhanced our understanding of the mechanism of action of the Fc gamma RIIB 1232T polymorphism and the overall role of this receptor in SLE. The human neutrophil antigen-1 allotypes of Fc gamma RIIIB and the role of the receptor in SLE are discussed with regard to the recent determination of copy number variation in FCGR3B and the association of low copy number with SLE.