Inhibitory Activity of Fe3O4/Oleic Acid/Usnic Acid-Core/Shell/Extra-Shell Nanofluid on S. aureus Biofilm Development
Inhibitory Activity of Fe3O4/Oleic Acid/Usnic Acid-Core/Shell/Extra-Shell Nanofluid on S. aureus Biofilm Development
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DOI：
10.1109/tnb.2011.2178263
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发表时间：
2011-12-01
影响因子：
3.9
通讯作者：
Lazar, Veronica
中科院分区：
文献类型：
--
作者：
Grumezescu, Alexandru Mihai;Saviuc, Crina;Lazar, Veronica
不期望的生物膜发展是许多领域，特别是医学领域的主要关注点。本研究的目的是比较研究松萝酸在可溶性与纳米流体制剂中的控释膜功效，以突出Fe 3 O 4/油酸（FeOA）纳米流体作为该控释膜剂的潜在控释载体的潜在用途。纳米流体中的（+）-UA对S.金黄色葡萄球菌生物膜形成，通过活细胞计数的急剧减少以及通过共聚焦激光扫描显微镜图像揭示。我们的研究结果表明，FeOA纳米粒子可以用作成功的涂层剂，用于获得不同医疗设备上的抗菌膜薄膜，打开了一个新的视角，获得新的抗菌和抗菌膜表面，基于混合功能化纳米结构生物材料。
Undesired biofilm development is a major concern in many areas, especially in the medical field. The purpose of the present study was to comparatively investigate the antibiofilm efficacy of usnic acid, in soluble versus nanofluid formulation, in order to highlight the potential use of Fe3O4/oleic acid (FeOA) nanofluid as potential controlled release vehicle of this antibiofilm agent. The (+)-UA loaded into nanofluid exhibited an improved antibiofilm effect on S. aureus biofilm formation, revealed by the drastic decrease of the viable cell counts as well as by confocal laser scanning microscopy images. Our results demonstrate that FeOA nanoparticles could be used as successful coating agents for obtaining antibiofilm pellicles on different medical devices, opening a new perspective for obtaining new antimicrobial and antibiofilm surfaces, based on hybrid functionalized nanostructured biomaterials.