An automated system for rapid evaluation of high-density electrode arrays in neural prostheses
An automated system for rapid evaluation of high-density electrode arrays in neural prostheses
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DOI：
10.1088/1741-2560/8/3/036011
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发表时间：
2011-06-01
影响因子：
4
通讯作者：
Williams, Chris E.
中科院分区：
文献类型：
--
作者：
John, Sam E.;Shivdasani, Mohit N.;Williams, Chris E.
用于神经假体的高密度电极阵列的成功依赖于有效的阻抗监测和故障检测。传统的阻抗测试和故障检测方法非常耗时，并不总是适用于高密度电极阵列的在体评估。此外，在体外和体内评估阻抗和故障(如开路和短路)的能力对于确保安全有效的刺激非常重要。在这项工作中，我们描述了一个用于快速评估高密度电极阵列的自动化系统。该系统使用类似于刺激神经组织的电流脉冲，并测量电极两端的电压，以计算阻抗。通过模拟使用发光二极管和阻容网络的高密度电极阵列，验证了系统的开关。该系统在体外和体内使用了一系列商业上可用的和内部开发的电极阵列进行测试。该系统在不到20个S的时间内准确地识别了84个电极阵列中的故障，并使用200 mA、每相250 mU的S电流脉冲可靠地测量了高达110k Omega的阻抗。该系统可直接应用于临床和实验环境中高密度电极阵列的筛选。
The success of high-density electrode arrays for use in neural prostheses depends on efficient impedance monitoring and fault detection. Conventional methods of impedance testing and fault detection are time consuming and not always suited for in vivo assessment of high-density electrode arrays. Additionally, the ability to evaluate impedances and faults such as open and short circuits, both in vitro and in vivo, are important to ensure safe and effective stimulation. In this work we describe an automated system for the rapid evaluation of high-density electrode arrays. The system uses a current pulse similar to that used to stimulate neural tissue and measures the voltage across the electrode in order to calculate the impedance. The switching of the system was validated by emulating a high-density electrode array using light-emitting diodes and a resistor-capacitor network. The system was tested in vitro and in vivo using a range of commercially available and in-house developed electrode arrays. The system accurately identified faults in an 84-electrode array in less than 20 s and reliably measured impedances up to 110 k Omega using a 200 mu A, 250 mu s per phase current pulse. This system has direct application for screening high-density electrode arrays in both clinical and experimental settings.