Yearlong physical activity and sarcopenia in older adults: the Nakanojo Study
Yearlong physical activity and sarcopenia in older adults: the Nakanojo Study
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DOI：
10.1007/s00421-010-1424-8
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发表时间：
2010-07-01
影响因子：
3
通讯作者：
Aoyagi, Yukitoshi
中科院分区：
文献类型：
--
作者：
Park, Hyuntae;Park, Sungjin;Aoyagi, Yukitoshi
我们测试了这样的假设：老年人日常体力活动水平低与临床上显着程度的肌肉减少症有关。受试者为 78 名男性和 97 名女性自由生活的日本人，年龄在 65 至 84 岁之间。计步器/加速计连续测量一年内每天 24 小时的步数和活动强度。年底，全身双 X 射线吸收测量扫描评估了上肢和下肢的骨骼肌质量。肌肉减少症的定义是肌肉质量/身高 (2) 值比健康年轻日本人的平均值低 > 1 SD。线性和指数回归表明，在控制年龄和/或性别数据后，肌肉质量与体力活动的相关性更高，腿部的肌肉质量比手臂的肌肉质量更紧密，中等活动持续时间（> 3 MET）的肌肉质量与步数的相关性更强。肌肉质量随着日常活动逐渐增加，尽管当数据被分类为四分位数时，男性和女性的肌肉质量并没有显着增加，分别超过每天 8,000 和 6,900 步和/或每天超过 3 MET 的 22 和 19 分钟。所有符合此类标准的参与者都超过了我们的肌少症阈值。多变量调整逻辑回归预测，每天步行< 5,300步和/或每天花费> 3 MET的时间< 15分钟的个体，与每天步行> 7,800步和/或每天花费> 3 MET的时间> 23分钟的个体相比，出现肌肉减少症的可能性分别高出2.00-2.66和/或2.03-4.55倍。我们的假设被证明是正确的：每天步行至少 7,000-8,000 步和/或每天花费 15-20 分钟，强度 > 3 MET 的老年人可能拥有高于肌肉减少症阈值的肌肉质量。
We tested the hypothesis that a low level of regular daily physical activity in elderly individuals would be associated with a clinically significant degree of sarcopenia. Subjects were 78 male and 97 female free-living Japanese, aged 65-84 years. A pedometer/accelerometer measured continuously the number of steps taken and the intensity of activity 24 h/day for 1 year. A whole-body dual X-ray absorptiometry scan assessed skeletal muscle mass in the upper and lower extremities at the end of the year. Sarcopenia was defined as a muscle mass/height(2) value > 1 SD below the mean for healthy young Japanese. Linear and exponential regressions showed that after controlling data for age and/or sex, muscle mass was associated with physical activity, more closely for the legs than for the arms, and for duration of moderate activity (> 3 METs) than for step count. Muscle mass increased progressively with daily activity, although when data were categorized into quartiles, muscle mass was not significantly greater in men and women who exceeded, respectively, 8,000 and 6,900 steps/day and/or 22 and 19 min/day at > 3 METs. All participants meeting such criteria exceeded our sarcopenia threshold. Multivariate-adjusted logistic regressions predicted that individuals who walked < 5,300 steps/day and/or spent < 15 min/day at > 3 METs were, respectively, 2.00-2.66 and/or 2.03-4.55 times more likely to show sarcopenia than those who walked > 7,800 steps/day and/or spent > 23 min/day at > 3 METs. Our hypothesis was proven correct: seniors who walked at least 7,000-8,000 steps/day and/or spent 15-20 min/day at an intensity of > 3 METs were likely to have a muscle mass above the sarcopenia threshold.