Robust Ionic Current Sensor for Bacterial Cell Size Detection
Robust Ionic Current Sensor for Bacterial Cell Size Detection
复制标题
用于细菌细胞大小检测的稳健离子电流传感器
DOI：
10.1021/acssensors.8b00045
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发表时间：
2018
期刊：
影响因子：
8.9
通讯作者：
T. Kawai and Y. Baba
中科院分区：
文献类型：
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作者：
H. Yasaki;T. Shimada;T. Yasui;T. Yanagida;N. Kaji;M. Kanai;K. Nagashima;T. Kawai and Y. Baba
离子电流感测方法是用于检测亚微米至几微米级颗粒（诸如细菌）的有用工具。然而，常规的市售离子电流感测装置由于其鲁棒性的固有限制而不适合于现场测量使用。在这里，我们提出了一个便携式的强大的离子电流传感器（Robust-ICS）使用的桥式电路，提供了一个高的信号噪声比（S/N）比，通过抑制背景电流。由于Robust-ICS可以容忍电流检测中增加的噪声，因此可以使用简单、轻便的电磁屏蔽，并可以在大电磁噪声条件下进行测量。该设备的重量降低到4 kg以下，并成功完成了室外颗粒物检测测量。金黄色葡萄球菌（S.金黄色葡萄球菌）的结果与通过SEM成像获得的结果相当。
Ionic current sensing methods are useful tools for detecting sub- to several-micron scale particles such as bacteria. However, conventional commercially available ionic current sensing devices are not suitable for on-site measurement use because of inherent limitations on their robustness. Here, we proposed a portable robust ionic current sensor (Robust-ICS) using a bridge circuit that offers a high signal-to-noise (S/N) ratio by suppressing background current. Because the Robust-ICS can tolerate increased noise in current sensing, a simple, lightweight electromagnetic shield can be used and measurements under large electromagnetic noise conditions can be made. The weight of the device was lowered below 4 kg and outdoor particle detection measurements were completed successfully. Accuracy of size detection ofStaphylococcus aureus(S. aureus) was equivalent to that obtained by SEM imaging.