Estimation of absorption of aromatic hydrocarbons diffusing from interior materials in automobile cabins by inhalation toxicokinetic analysis in rats
Estimation of absorption of aromatic hydrocarbons diffusing from interior materials in automobile cabins by inhalation toxicokinetic analysis in rats
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通过大鼠吸入毒代动力学分析估算汽车座舱内饰材料中芳香烃的吸收量
DOI：
10.1002/jat.1522
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发表时间：
2010
影响因子：
3.3
通讯作者：
Toshiaki Yoshida
中科院分区：
文献类型：
--
作者：
Toshiaki Yoshida
芳香族碳氢化合物以及脂肪族碳氢化合物从汽车车厢的内部材料中扩散，是导致内部空气污染的最常见化合物。本研究通过对大鼠吸入的7种芳烃进行毒理学评价，估计了汽车驾驶员对这些芳烃的吸入量。将测定量的这些物质注射到含有大鼠的封闭室系统中，并检查室中的浓度变化。使用非线性房室模型，基于浓度-时间过程评价了物质的毒代动力学。根据从大鼠身上获得的结果，推断出在没有通风设备的汽车车厢中人体实际吸收的浓度。驾驶员在2小时驾驶期间的吸收量估计如下（每60公斤人体体重）：30 µg甲苯（内部中位浓度，在我们之前的研究中为40 µg m−3），（12 µg m−3）、邻二甲苯6 µg（10 µg m−3）、间二甲苯8 µg（11 µg m−3）、对二甲苯9 µg（11 µ g m−3）、苯乙烯11 µg（11 µ g m−3）和1，2，4-三甲基苯27 µg（24 µg m−3）。同样，在空气污染明显的舱室中，苯乙烯的吸收量（在舱室内部最大浓度为675 µg m−3的情况下，2小时内为654 µg）估计远高于其他物质。该含量（654 µg）约为世界卫生组织推荐的苯乙烯每日可耐受摄入量（每天7.7 µg kg-1）的1.5倍。版权所有© 2010约翰威利父子有限公司.
Aromatic hydrocarbons, as well as aliphatic hydrocarbons, diffusing from interior materials in automotive cabins are the most common compounds contributing to interior air pollution. In this study, the amounts of seven selected aromatic hydrocarbons absorbed by a car driver were estimated by evaluating their inhalation toxicokinetics in rats. Measured amounts of these substances were injected into a closed chamber system containing a rat, and the concentration changes in the chamber were examined. The toxicokinetics of the substances were evaluated on the basis of the concentration–time course using a nonlinear compartment model. The amounts absorbed in humans at actual concentrations in automobile cabins without ventilation were extrapolated from the results obtained from rats. The absorbed amounts estimated for a driver during a 2 h drive were as follows (per 60 kg of human body weight): 30 µg for toluene (interior median concentration, 40 µg m−3 in our previous study), 10 µg for ethylbenzene (12 µg m−3), 6 µg for o‐xylene (10 µg m−3), 8 µg for m‐xylene (11 µg m−3), 9 µg for p‐xylene (11 µg m−3), 11 µg for styrene (11 µg m−3) and 27 µg for 1,2,4‐trimethylbenzene (24 µg m−3). Similarly, in a cabin where air pollution was marked, the absorbed amount of styrene (654 µg for 2 h in a cabin with an interior maximum concentration of 675 µg m−3) was estimated to be much higher than those of other substances. This amount (654 µg) was approximately 1.5 times the tolerable daily intake of styrene (7.7 µg kg−1 per day) recommended by the World Health Organization. Copyright © 2010 John Wiley & Sons, Ltd.
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DOI：
--
发表时间：
2002
期刊：
IARC monographs on the evaluation of carcinogenic risks to humans
影响因子：
--
作者：
Iarc Monographs
通讯作者：
Iarc Monographs
通过半经验生理学模型评估 2H8-甲苯毒代动力学的个体差异。
影响因子：
3.8
作者：
Pierce,CH;Dills,RL;Morgan,MS;Nothstein,GL;Shen,DD;Kalman,DA
通讯作者：
Kalman,DA
1H8- 和 2H8- 甲苯在男性中的毒代动力学比较。
DOI：
10.1080/004982599238830
发表时间：
1999
期刊：
Xenobiotica; the fate of foreign compounds in biological systems
影响因子：
--
作者：
Pierce,CH;Lewandowski,TA;Dills,RL;Morgan,MS;Wessels,MA;Shen,DD;Kalman,DA
通讯作者：
Kalman,DA
人体血液或脂肪组织与空气对芳香族溶剂的分配系数。
DOI：
10.5271/sjweh.119
发表时间：
1996
期刊：
Scandinavian journal of work, environment & health
影响因子：
--
作者：
Pierce,CH;Dills,RL;Silvey,GW;Kalman,DA
通讯作者：
Kalman,DA