Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City.
Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City.
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DOI：
10.1289/ehp.1510266
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发表时间：
2016-08
影响因子：
10.4
通讯作者：
Matte T
中科院分区：
文献类型：
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作者：
Johnson S;Bobb JF;Ito K;Savitz DA;Elston B;Shmool JL;Dominici F;Ross Z;Clougherty JE;Matte T
最近的研究表明，空气污染与各种出生结果之间存在关联，但早产的证据好坏参半。我们的目的是评估空气污染和早产之间的关系，使用2008-2010年纽约市（NYC）的出生证明与医院记录。我们分析了258，294例妊娠22-42周的非吸烟母亲的单胎分娩。暴露于环境中的细颗粒物（PM2.5）和二氧化氮（NO2）在第一，第二，和累积的第三孕期内300米的产妇地址估计使用的数据从纽约市社区空气调查和监管监测。我们在logistic混合模型中估计了早期和中期妊娠暴露的自发性早产（妊娠< 37周）的比值比（OR），并在离散时间生存模型中估计了晚期妊娠累积暴露，调整了母体特征和分娩医院。还分别分析了估计暴露的空间和时间分量。PM2.5与自发性早产无显著相关性。在调整后的模型中，妊娠中期NO2与自发性早产呈负相关（OR = 0.90; 95%CI：0.83，0.97每20 ppb）。根据调整后的时间暴露模型，两种污染物均与自发性早产无显著相关性，而空间暴露显示出显著降低的比值比（OR = 0.80; 95%CI：0.67，0.96/10 μg/m3 PM2.5和0.88; 95%CI：0.79，0.98/20 ppb NO2）。如果没有医院的调整，这些负面的协会更强。PM2.5和NO2均与纽约市自发性早产无显著相关性。分娩医院是一个重要的空间混杂因素。约翰逊S，BobB JF，Ito K，Savitz DA，Elston B，Shmool JL，Dominici F，Ross Z，Cloughnut JE，Matte T. 2016.纽约市环境细颗粒物、二氧化氮和早产。环境健康展望124：1283-1290; http：dx.doi.org/10.1289/ehp.1510266
Recent studies have suggested associations between air pollution and various birth outcomes, but the evidence for preterm birth is mixed. We aimed to assess the relationship between air pollution and preterm birth using 2008–2010 New York City (NYC) birth certificates linked to hospital records. We analyzed 258,294 singleton births with 22–42 completed weeks gestation to nonsmoking mothers. Exposures to ambient fine particles (PM2.5) and nitrogen dioxide (NO2) during the first, second, and cumulative third trimesters within 300 m of maternal address were estimated using data from the NYC Community Air Survey and regulatory monitors. We estimated the odds ratio (OR) of spontaneous preterm (gestation < 37 weeks) births for the first- and second-trimester exposures in a logistic mixed model, and the third-trimester cumulative exposures in a discrete time survival model, adjusting for maternal characteristics and delivery hospital. Spatial and temporal components of estimated exposures were also separately analyzed. PM2.5 was not significantly associated with spontaneous preterm birth. NO2 in the second trimester was negatively associated with spontaneous preterm birth in the adjusted model (OR = 0.90; 95% CI: 0.83, 0.97 per 20 ppb). Neither pollutant was significantly associated with spontaneous preterm birth based on adjusted models of temporal exposures, whereas the spatial exposures showed significantly reduced odds ratios (OR = 0.80; 95% CI: 0.67, 0.96 per 10 μg/m3 PM2.5 and 0.88; 95% CI: 0.79, 0.98 per 20 ppb NO2). Without adjustment for hospital, these negative associations were stronger. Neither PM2.5 nor NO2 was positively associated with spontaneous preterm delivery in NYC. Delivery hospital was an important spatial confounder. Johnson S, Bobb JF, Ito K, Savitz DA, Elston B, Shmool JL, Dominici F, Ross Z, Clougherty JE, Matte T. 2016. Ambient fine particulate matter, nitrogen dioxide, and preterm birth in New York City. Environ Health Perspect 124:1283–1290; http://dx.doi.org/10.1289/ehp.1510266