Disorders of aldosterone biosynthesis and action.
Disorders of aldosterone biosynthesis and action.
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DOI：
10.1056/nejm199407283310408
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发表时间：
1994-07
期刊：
影响因子：
--
通讯作者：
P. White
中科院分区：
文献类型：
--
作者：
P. White
阿狄森氏病患者在尿中排出过量的钠，但保留了钾，从而成为低钠血症和高钾血症。早期的研究表明，人类和动物的问题可以通过服用肾上腺提取物得到改善1,2。这些提取物被认为含有保持钠或矿化皮质激素特性的激素。然而，直到分离出一种具有强效矿化皮质活性的新型类固醇后，才证实了不同矿化皮质激素的存在。这种激素被命名为醛固酮，以承认其独特的结构特征，即C18上的醛基。本文综述了矿皮质激素缺乏或过量的情况，重点介绍了矿皮质激素。
Patients with Addison's disease excrete excessive amounts of sodium in the urine but retain potassium, thus becoming hyponatremic and hyperkalemic. Early studies demonstrated that the problems could be ameliorated in humans and animals by administering extracts from adrenal glands1,2. These extracts were presumed to contain hormones with sodium-retaining, or mineralocorticoid, properties. The existence of distinct mineralocorticoids was, however, not proved until a novel steroid with potent mineralocorticoid activity was isolated3. This hormone was named aldosterone to acknowledge its unique structural feature, an aldehyde group at C18. This article reviews conditions of mineralocorticoid deficiency or excess, concentrating on . . .