Dual role of B cells in mediating innate and acquired immunity to herpes simplex virus infections
Dual role of B cells in mediating innate and acquired immunity to herpes simplex virus infections
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DOI：
10.1006/cimm.2000.1666
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发表时间：
2000-06-15
影响因子：
4.3
通讯作者：
Rouse, BT
中科院分区：
文献类型：
--
作者：
Deahpande, SP;Kumaraguru, U;Rouse, BT
敏感BALB/c品系和抗性C57 B1/6品系的μ-免疫球蛋白链基因靶向的B细胞缺陷小鼠对单纯疱疹病毒（HSV）的皮肤感染的敏感性比相应的对照野生型小鼠高100- 1000倍。分析了缺乏B细胞对HSV感染的免疫力的影响，发现B细胞在影响先天性和获得性免疫应答中起双重作用。与HSV反应的天然抗体（IgM同种型）在原发性皮肤HSV感染的先天性控制中具有抗病毒作用，B细胞也可以作为抗原呈递细胞用于刺激HSV特异性CD 4 + T细胞应答。因此，与对照小鼠相比，HSV感染的E细胞缺陷小鼠中的CD 4 + T细胞和干扰素-γ应答显著受损。在对照和B细胞缺陷小鼠之间，未发现自然杀伤细胞或HSV特异性CD 8 + T细胞活性的显著差异。我们的研究结果暗示了B细胞在介导先天免疫和CD 4 + T细胞特异性免疫中的作用，决定了对原发性HSV感染的易感性。(C)北京大学出版社.
mu-Immunoglobulin chain gene targeted B-cell-deficient mice of susceptible BALB/c strain and resistant C57B1/6 strain are up to 100- to 1000-fold more susceptible to cutaneous infection by herpes simplex virus (HSV) than the respective control wild type mice. The effect of the lack of B cells on immunity to HSV infections was analyzed and B cells were found to play a dual role in affecting both innate and acquired immune responses. Natural antibodies (IgM isotype), reactive with HSV have an anti-viral effect in the innate control of primary cutaneous HSV infection, B cells can also function as antigen-presenting cells for the stimulation of HSV-specific CD4+ T-cell responses. Consequently, CD4+ T cells and interferon-gamma responses were found to be significantly impaired in HSV-infected E-cell-deficient mice compared to that seen in control mice, No significant differences were found in natural-killer-cell- or HSV-specific CD8+ T-cell activity between control and B-cell-deficient mice. Our results imply a role for B cell in mediating innate and CD4+ T-cell-specific immunity in determining susceptibility to primary HSV infections. (C) 2000 Academic Press.