Nonalcoholic fatty liver disease in a district general hospital: clinical presentation and risk factors
Nonalcoholic fatty liver disease in a district general hospital: clinical presentation and risk factors
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DOI：
10.1007/s12072-008-9044-7
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发表时间：
2008-06-01
影响因子：
6.6
通讯作者：
Bateman, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Syn, Wing-Kin;Nightingale, Peter;Bateman, Jeffrey M.
简介 非酒精性脂肪肝病 (NAFLD) 影响着五分之一的成年人口，是目前西方世界最常见的肝脏问题。未来几十年，NAFLD 的患病率可能会随着肥胖和糖尿病的流行而上升。英国进行了一项回顾性研究。地区综合医院 (DGH) 确定 NAFLD 患者的临床和实验室特征。方法和结果 总共确定了 48 名 NAFLD 患者。大多数（54%）患者就诊时无症状，90% 的患者超声检查（USS）显示肝脏回声增强。大多数人的肝脏检测结果升高，但无法区分单纯性脂肪变性和脂肪性肝炎。具有代谢综合征特征和低血小板计数（P = 0.028）可能有助于识别晚期肝纤维化患者。 结论 NAFLD 在 DGH 中很常见，所有具有代谢危险因素的患者都应予以考虑。对于患有低血小板、II 型糖尿病和代谢综合征的患者，应考虑进行肝活检。
Introduction Nonalcoholic fatty liver disease (NAFLD) affects one-fifth of the adult population and is currently the commonest liver problem in the western world. The prevalence of NAFLD is likely to rise over the coming decades in parallel to the obesity and diabetes epidemics. A retrospective study was undertaken in a UK. district general hospital (DGH) to determine the clinical and laboratory features of patients with NAFLD.Methods and findings A total of 48 patients with NAFLD were identified. Most (54%) were asymptomatic on presentation and 90% had an echogenic liver on ultrasonography (USS). Liver tests were elevated in the majority, but did not distinguish between simple steatosis and steatohepatitis. Having features of the metabolic syndrome and a low platelet count (P = 0.028) may help identify patients with advanced hepatic fibrosis.Conclusions NAFLD is common in the DGH and should be considered in all patients with metabolic risk factors. A liver biopsy should be considered in those with low platelets, type II diabetes mellitus, and the metabolic syndrome.