Highly enantioselective construction of carbazole derivatives via [4 2] cycloaddition of silyloxyvinylindoles and beta,gamma-unsaturated alpha-ketoesters
Highly enantioselective construction of carbazole derivatives via [4 2] cycloaddition of silyloxyvinylindoles and beta,gamma-unsaturated alpha-ketoesters
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通过甲硅烷氧基乙烯基吲哚和β,γ-不饱和α-酮酯的[4 2]环加成高度对映选择性构建咔唑衍生物
DOI：
10.1039/c6cc05328a
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发表时间：
2016
影响因子：
4.9
通讯作者：
Feng Xiaoming
中科院分区：
文献类型：
--
作者：
Zhao Xiaohu;Mei Hongjiang;Xiong Qian;Fu Kai;Lin Lili;Liu Xiaohua;Feng Xiaoming
用手性N，N′-二氧化物/三氟甲磺酸钇配合物催化硅氧基乙烯基吲哚与β，γ-不饱和α-酮酯的不对称[4+2]环加成反应。在温和的反应条件下，以47-98%的产率和86-99%的ee得到了广泛的咔唑衍生物。
A highly efficient catalytic asymmetric [4+2] cycloaddition of silyloxyvinylindoles with β,γ-unsaturated α-ketoesters has been accomplished by an available chiral N,N′-dioxide/yttrium triflate complex. A widespread range of carbazole derivatives were obtained in 47–98% yield with 86–99% ee under mild reaction conditions.