EFFECT OF PREPARATION CONDITIONS ON MORPHOLOGY AND PERFORMANCE OF HEMODIALYSIS MEMBRANES PREPARED FROM POLYETHER SULPHONE AND POLYVINYLPYRROLIDONE
EFFECT OF PREPARATION CONDITIONS ON MORPHOLOGY AND PERFORMANCE OF HEMODIALYSIS MEMBRANES PREPARED FROM POLYETHER SULPHONE AND POLYVINYLPYRROLIDONE
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
J. Barzin;S. S. Madaeni-S.;Mirzadeh Hamid
中科院分区：
文献类型：
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作者：
J. Barzin;S. S. Madaeni-S.;Mirzadeh Hamid
以12% （wt）聚醚砜（PES）和2.8% （wt）聚乙烯吡罗烷酮（PVP）溶解在二甲基乙酰胺（DMAc）中，采用相转化法制备了平板血液透析膜。在直接去除血清中尿毒症毒素的基础上，研究了膜的性能。用间歇式透析仪将膜与人血清接触，在医学实验室按标准方法测定尿素、尿酸和肌酐的去除。研究了凝血浴温度和聚合物溶液温度对膜形态和血液透析性能的影响。SEM显微图显示出典型的不对称通道状结构，其大小和数量随制备条件的不同而变化。膜的结构取决于混凝过程中溶剂分子和非溶剂分子的扩散速率。聚合物溶液和混凝液的温度是混凝过程中最重要的参数之一。血液透析膜的性能和形态研究表明，通过增大混凝液和聚合物溶液的温差，可以增大通道状结构的尺寸。在60°C的混凝浴和23°C的聚合物溶液温度下制备的膜可以去除84%的尿素，71%的尿酸和53%的肌酐。L929成纤维细胞在PES膜上的培养试验显示出良好的生物相容性。膜;
Flat-sheet hemodialysis membranes were prepared with 12% (wt) polyether sulphone (PES) and 2.8% (wt) polyvinylpyrrolidone (PVP) dissolved in dimethylacetamide (DMAc) by phase inversion method. The performances of membranes were investigated on the basis of direct removal of uremic toxins from blood serum. The membranes were put in contact with human blood serum in a batch dialyzer instrument and removal of urea, uric acid and creatinine were measured in a medical laboratory according to the standard methods. The effects of temperatures of coagulation bath and polymer solution on membrane morphology and hemodialysis performance were investigated. The SEM micrographs showed typical asymmetric channel-like structures, which their sizes and numbers change with different preparation conditions. Membrane structure depends on the diffusion rate of solvent and non-solvent molecules in the coagulation process. The temperatures of polymer solution and coagulation bath are among the most important parameters of the coagulation processes. The performance and morphology studies of hemodialysis membrane indicated that by increasing the temperature difference between coagulation bath and polymer solution temperatures, the sizes of channellike structures were increased. A removal of 84% urea, 71% uric acid, and 53% creatinine was attained by a membrane prepared at 60°C coagulation bath and 23°C polymer solution temperatures. The L929 fibroblast cell culture test on PES membranes showed excellent biocompability. membrane;