Estimating the alcohol-breast cancer association: a comparison of diet diaries, FFQs and combined measurements
Estimating the alcohol-breast cancer association: a comparison of diet diaries, FFQs and combined measurements
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DOI：
10.1007/s10654-012-9693-7
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发表时间：
2012-07-01
影响因子：
13.6
通讯作者：
Khaw, Kay-Tee
中科院分区：
文献类型：
--
作者：
Keogh, Ruth H.;Park, Jin Young;Khaw, Kay-Tee
酒精与乳腺癌的关系是通过食物频率调查表（FFQ）中的酒精摄入量测量建立的。对于某些营养素，与FFQ测量相比，饮食日记测量与真实摄入量的相关性更高，但对于酒精是否如此尚不清楚。一项病例对照研究（656例乳腺癌病例，1905例匹配对照）从英国饮食队列联盟的四个队列中取样。使用FFQ和4天或7天饮食日记前瞻性地测量酒精摄入量。两者都依赖于分配给给定饮料类型的固定份量，但用于获得FFQ测量的份量较低。因此，FFQ测量值平均较低，为了进行公平比较，使用饮食日记部分大小“校准”FFQ。饮食日记给出了更多的零测量值，证明了使用短期仪器区分从未发作的消费者的挑战。为了使用所有信息，计算了两个组合测量值。第一个是两个测量值的平均值，并对零点进行特殊处理。第二个是预期的真实摄入量给定的两个测量，使用测量误差模型计算。在混杂因素调整后，使用饮食日记和FFQ时，每10 g/天酒精摄入量的比值比（OR）分别为1.05（95% CI 0.98，1.13）和1.13（1.02，1.24）。经校准的FFQ测量值和组合测量值1和2分别给出OR 1.10（1.03，1.18）、1.09（1.01，1.18）、1.09（0.99，1.20）。HRT的使用改变了这种关联，使用者比非使用者更强。总之，与FFQ相比，在一个时间点使用饮食日记中的酒精测量值的相关性减弱。
The alcohol-breast cancer association has been established using alcohol intake measurements from Food Frequency Questionnaires (FFQ). For some nutrients diet diary measurements are more highly correlated with true intake compared with FFQ measurements, but it is unknown whether this is true for alcohol. A case-control study (656 breast cancer cases, 1905 matched controls) was sampled from four cohorts in the UK Dietary Cohort Consortium. Alcohol intake was measured prospectively using FFQs and 4- or 7-day diet diaries. Both relied on fixed portion sizes allocated to given beverage types, but those used to obtain FFQ measurements were lower. FFQ measurements were therefore on average lower and to enable fair comparison the FFQ was "calibrated" using diet diary portion sizes. Diet diaries gave more zero measurements, demonstrating the challenge of distinguishing never-from episodic-consumers using short term instruments. To use all information, two combined measurements were calculated. The first is an average of the two measurements with special treatment of zeros. The second is the expected true intake given both measurements, calculated using a measurement error model. After confounder adjustment the odds ratio (OR) per 10 g/day of alcohol intake was 1.05 (95 % CI 0.98, 1.13) using diet diaries, and 1.13 (1.02, 1.24) using FFQs. The calibrated FFQ measurement and combined measurements 1 and 2 gave ORs 1.10 (1.03, 1.18), 1.09 (1.01, 1.18), 1.09 (0.99,1.20), respectively. The association was modified by HRT use, being stronger among users versus non-users. In summary, using an alcohol measurement from a diet diary at one time point gave attenuated associations compared with FFQ.