Krüppel-like factor (KLF)5: An emerging foe of cardiovascular health.
Krüppel-like factor (KLF)5: An emerging foe of cardiovascular health.
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DOI：
10.1016/j.yjmcc.2021.10.002
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发表时间：
2022-03
影响因子：
5
通讯作者：
Drosatos K
中科院分区：
文献类型：
--
作者：
Palioura D;Lazou A;Drosatos K
KRüppel样因子(KLF)是一类DNA结合的转录因子，调节与发育、代谢和其他细胞机制有关的各种途径。KLF5于1993年首次被克隆，到1999年被报道为肠道富集型KLF5。除了发现KLF5与正常发育和癌症有关外，它还与各种类型的心血管(CV)并发症以及肝脏、心脏、脂肪组织和骨骼肌代谢途径的调节有关。具体地说，KLF5表达增加与糖尿病、终末期心力衰竭以及血管动脉粥样硬化病变的心肌病有关。在这篇综述文章中，我们总结了关于KLF5转录、转录后和翻译后调节的研究结果，以及KLF5在直接或间接影响心血管健康的细胞和器官生物学中的作用。最后，我们建议抑制KLF5作为一种新的心血管治疗方法。
Krüppel-like factors (KLFs) are DNA-binding transcriptional factors, which regulate various pathways that pertain to development, metabolism and other cellular mechanisms. KLF5 was first cloned in 1993 and by 1999, it was reported as the intestinal-enriched KLF. Beyond findings that have associated KLF5 with normal development and cancer, it has been associated with various types of cardiovascular (CV) complications and regulation of metabolic pathways in the liver, heart, adipose tissue and skeletal muscle. Specifically, increased KLF5 expression has been linked with cardiomyopathy in diabetes, end-stage heart failure, and as well as in vascular atherosclerotic lesions. In this review article, we summarize research findings about transcriptional, post-transcriptional and post-translational regulation of KLF5, as well as the role of KLF5 in the biology of cells and organs that affect cardiovascular health either directly or indirectly. Finally, we propose KLF5 inhibition as an emerging approach for cardiovascular therapeutics.
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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