The effect of ageing on grey and white matter reductions in schizophrenia
The effect of ageing on grey and white matter reductions in schizophrenia
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DOI：
10.1016/j.schres.2009.04.023
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发表时间：
2009-07-01
影响因子：
4.5
通讯作者：
Grasby, Paul M.
中科院分区：
文献类型：
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作者：
Bose, Subrata K.;Mackinnon, Toby;Grasby, Paul M.
精神分裂症患者的总脑体积，特别是灰质(GM)体积减少，最近的研究表明，精神分裂症患者的脑体积进行性丢失比正常对照组更严重。然而，由于纵向研究不包括终身随访，目前尚不清楚这是发生在整个生命周期还是仅发生在疾病的早期阶段。在这项研究中，我们通过研究年龄对精神分裂症(n=34，年龄范围=27-65岁)脑组织体积的影响来研究这一点，以检验与健康对照组(n=33，年龄范围=18-73岁)相比，患者灰质体积随着年龄的增加而进行性丢失的预测。结果表明，与我们的预测相反，精神分裂症患者随着年龄的增长，GM体积的相对损失比对照组减少。然而，精神分裂症患者的相对白质(WM)丢失随年龄增长而增加。这一结果也重复了先前的发现，即与匹配的健康志愿者相比，精神分裂症患者的总体(1509比1596 mm(3))和局部GM体积(755比822 mm(3))显著减少，脑脊液(CSF)体积增加。总体而言，这些发现表明，精神分裂症患者的灰质比例在疾病早期比对照组减少，这种差异随着年龄的增加而减少；与对照组相比，WM比例的相应影响是随着年龄的增加而增加。这表明疾病相关因素可能不同地影响灰质和白质，这意味着理解精神分裂症和相关精神障碍的病理生理学。(C)2009爱思唯尔B.V.保留所有权利。
Total brain volume and, in particular gray matter (GM) volume is reduced in patients with schizophrenia and recent studies suggest there is greater progressive loss of brain volume in the patients with schizophrenia than in normal controls. However, as the longitudinal studies do not include life-long follow-up, it is not clear if this occurs across the lifespan or only in the early phase of the illness. In this study we investigated this by studying the effects of age on brain tissue volumes in schizophrenia (n = 34, age range = 27-65 years)to test the prediction that there is a progressive loss in grey matter volume with increasing age in patients compared to healthy controls (n = 33, age range = 18-73 years). The results showed there was diminished relative GM volume loss with age in patients with schizophrenia compared to controls - in contrast to our prediction. However, there was increased relative white matter (WM) loss with age in schizophrenia. The results also replicated previous findings that patients with schizophrenia have significantly lower total (1509 versus 1596 mm(3)) and regional GM volume (755 versus 822 mm(3)) and increased cerebrospinal fluid (CSF) volume when compared to matched healthy volunteers. Overall these findings indicate that the proportion of grey matter in schizophrenia is reduced compared to controls early in the illness, and this difference diminishes with age; the corresponding effect in the proportion of WM is an increase with age compared to controls. This suggests that illness related factors may differentially affect grey and white matter, with implications for understanding the pathophysiology of schizophrenia and related psychotic disorders. (C) 2009 Elsevier B.V. All rights reserved.