MicroRNA regulation of natural killer cells.
MicroRNA regulation of natural killer cells.
复制标题
DOI：
10.3389/fimmu.2013.00044
复制
发表时间：
2013
影响因子：
7.3
通讯作者：
Fehniger TA
中科院分区：
文献类型：
--
作者：
Sullivan RP;Leong JW;Fehniger TA
Natural killer (NK) cells are innate immune lymphocytes critical for host defense against viral infection and surveillance against malignant transformation. MicroRNAs (miRNAs) are a family of small, non-coding RNAs that regulate a wide variety of cellular processes. Recent advances have highlighted the importance of miRNA-mediated post-transcriptional regulation in NK cell development, maturation, and function. This review focuses on several facets of this regulatory mechanism in NK cells: (1) the expressed NK cell miRNA transcriptome; (2) the impact of total miRNA deficiency on NK cells; (3) the role of specific miRNAs regulating NK cell development, survival, and maturation; (4) the intrinsic role of miRNAs regulating NK cell function, including cytokine production, proliferation, and cytotoxicity; and (5) the role of NK cell miRNAs in disease. Currently our knowledge of how miRNAs regulate NK cell biology is limited, and thus we also explore key open questions in the field, as well as approaches and techniques to ascertain the role of individual miRNAs as important molecular regulators.
登录
查看更多内容
影响因子：
20.3
作者：
Eckelhart, Eva;Warsch, Wolfgang;Sexl, Veronika
通讯作者：
Sexl, Veronika
影响因子：
3.7
作者：
Allantaz F;Cheng DT;Bergauer T;Ravindran P;Rossier MF;Ebeling M;Badi L;Reis B;Bitter H;D'Asaro M;Chiappe A;Sridhar S;Pacheco GD;Burczynski ME;Hochstrasser D;Vonderscher J;Matthes T
通讯作者：
Matthes T
尖端：IL-18对NK细胞的启动。
DOI：
10.4049/jimmunol.181.3.1627
发表时间：
2008-08-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chaix J;Tessmer MS;Hoebe K;Fuséri N;Ryffel B;Dalod M;Alexopoulou L;Beutler B;Brossay L;Vivier E;Walzer T
通讯作者：
Walzer T
DOI：
10.1073/pnas.0500613102
发表时间：
2005-03-08
影响因子：
11.1
作者：
Eis, PS;Tam, W;Dahlberg, JE
通讯作者：
Dahlberg, JE
DOI：
10.1016/j.bbmt.2008.11.031
发表时间：
2009-02
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Bachanova V;McCullar V;Lenvik T;Wangen R;Peterson KA;Ankarlo DE;Panoskaltsis-Mortari A;Wagner JE;Miller JS
通讯作者：
Miller JS