Relation of alcohol use and smoking to glucose tolerance status in Japanese men.
Relation of alcohol use and smoking to glucose tolerance status in Japanese men.
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DOI：
10.1016/j.diabres.2005.12.010
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发表时间：
2006-07
影响因子：
5.1
通讯作者：
Y. Sakai;T. Yamaji;Shinji Tabata;S. Ogawa;K. Yamaguchi;M. Mineshita;T. Mizoue;S. Kono
中科院分区：
文献类型：
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作者：
Y. Sakai;T. Yamaji;Shinji Tabata;S. Ogawa;K. Yamaguchi;M. Mineshita;T. Mizoue;S. Kono
为了调查饮酒和吸烟与糖耐量状态的关系，我们对自卫队3038名年龄在46-59岁的男性官员进行了横断面研究。糖耐量状态通过75g口服葡萄糖耐量试验来确定。一份自填式问卷被用来确定饮酒、吸烟习惯和其他生活方式特征。对父母的糖尿病病史、体重指数和业余体力活动进行了统计调整。饮酒与空腹血糖受损、糖耐量受损和2型糖尿病均呈正相关。这种关联是剂量依赖的，即使在适度饮酒的人中，每一类葡萄糖耐量异常的几率也会增加。吸烟与任何类型的葡萄糖不耐受无关。饮酒不仅会增加患2型糖尿病的风险，还会增加既往的糖耐量异常的风险。吸烟似乎并不会恶化葡萄糖耐量。
To investigate the relation of alcohol use and cigarette smoking to glucose tolerance status, we performed a cross-sectional study of 3038 male officials aged 46–59 years in the Self-Defense Forces. Glucose tolerance status was determined by a 75-g oral glucose tolerance test. A self-administered questionnaire was used to ascertain alcohol use, smoking habits, and other lifestyle characteristics. Statistical adjustment was made for parental history of diabetes, body mass index, and leisure-time physical activity. Alcohol use was positively associated with impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes mellitus each. The association was dose-dependent, with odds of each category of glucose intolerance increased even among those with moderate alcohol use. Cigarette smoking was not related to any categories of glucose intolerance. Alcohol use may confer increased risks not only of type 2 diabetes mellitus but also of preceding glucose intolerance status. Smoking does not seem to deteriorate glucose tolerance.