Synthesis Characterization of a Ti-Zr-Based Alloy with Ultralow Young's Modulus and Excellent Biocompatibility
Synthesis Characterization of a Ti-Zr-Based Alloy with Ultralow Young's Modulus and Excellent Biocompatibility
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超低杨氏模量和优异生物相容性钛锆基合金的合成表征
DOI：
10.1002/adem.202100776
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发表时间：
2022
影响因子：
3.6
通讯作者：
S. Miyazaki
中科院分区：
文献类型：
--
作者：
K.M. Kim;Y. Al-Zain;A. Yamamoto;A.H. Daher;A.T. Mansour;J.M. AlAjlouni;A.S. Aloweidi;M.A. Al-Abbadi;H.Y. Kim;S. Miyazaki
近年来，亚稳β型钛合金因其低杨氏模量和优越的上级生物相容性，作为有前途的医用植入物材料而备受关注。前者取决于在热机械过程中发展的织构。因此，具有超低弹性模量和良好生物相容性的新型Ti-Zr-Nb-Sn-Mo合金被开发为有前途的医用植入材料。研究了Mo对Ti-18 Zr-5 Nb-3Sn系合金显微组织和力学性能的影响。X射线衍射（XRD）和扫描电子显微镜（SEM）结果表明Mo作为β相稳定剂。此外，力学行为和再结晶织构表现出很强的成分依赖性，2.5Mo合金表现出最低的杨氏模量为40 GPa。这是由于形成了具有较强高斯成分的再结晶织构<001>。2.5Mo合金在细胞培养基中的腐蚀行为与商业纯钛（cp-Ti）相似，表明在生物环境中具有优异的耐腐蚀性。鼠成纤维细胞和成骨细胞在2.5Mo合金上的生长良好，与cp‐Ti上的生长水平相同。植入大鼠皮下组织证实，2.5Mo合金和cp-Ti之间的组织反应无显著差异。
Recently, metastable β‐type Ti alloys have attracted attention as promising materials for medical implants due to low Young's modulus and superior biocompatibility. The former is dependent on texture developed during the thermomechanical process. Herein, new Ti–Zr–Nb–Sn–Mo alloys with ultralow Young's modulus and excellent biocompatibility are developed as promising materials for medical implants. The effect of Mo on the microstructure and mechanical properties of the Ti–18Zr–5Nb–3Sn system is investigated. X‐ray diffraction (XRD) and scanning electron microscope (SEM) results reveal that Mo acts as a β‐phase stabilizer. Moreover, mechanical behavior and recrystallization texture show strong composition dependence; the 2.5Mo alloy shows the lowest Young's modulus of 40 GPa. This is due to the formation of a recrystallization texture with strong Goss component of <001>. Corrosion behavior of the 2.5Mo alloy in the cell culture medium is similar to that of the commercially pure titanium (cp‐Ti), suggesting excellent corrosion resistance in the biological environment. Both murine fibroblasts and osteoblastic cells show good growth on the 2.5Mo alloy as the same level of that on the cp‐Ti. Implantation into rat subcutaneous tissue confirms no significant difference in the tissue reaction between the 2.5Mo alloy and the cp‐Ti.