Petri net modelling of biological networks
Petri net modelling of biological networks
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DOI：
10.1093/bib/bbm029
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发表时间：
2007-07-01
影响因子：
9.5
通讯作者：
Chaouiya, Claudine
中科院分区：
文献类型：
--
作者：
Chaouiya, Claudine
数学模型越来越多地用于深入了解复杂生物网络的功能。在这种背景下，Petri 网（PN）最近成为分子网络建模和分析所采用的各种方法中很有前途的工具。 PN 带有一系列扩展，允许不同的抽象级别，从纯粹的定性模型到更复杂的定量模型。值得注意的是，这些模型中的每一个都保留了底层图，该图描述了生物成分之间的相互作用。本文旨在介绍该方法的基础知识，并促进 PN 在计算系统生物学的发展中发挥的潜在作用。
Mathematical modelling is increasingly used to get insights into the functioning of complex biological networks. In this context, Petri nets (PNs) have recently emerged as a promising tool among the various methods employed for the modelling and analysis of molecular networks. PNs come with a series of extensions, which allow different abstraction levels, from purely qualitative to more complex quantitative models. Noteworthily, each of these models preserves the underlying graph, which depicts the interactions between the biological components. This article intends to present the basics of the approach and to foster the potential role PNs could play in the development of the computational systems biology.