Mechanism of Hepatocyte Apoptosis.
Mechanism of Hepatocyte Apoptosis.
复制标题
DOI：
10.4137/jcd.s39824
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Wang MJ
中科院分区：
文献类型：
--
作者：
Cao L;Quan XB;Zeng WJ;Yang XO;Wang MJ
肝细胞凋亡在清除外来微生物以及肝脏疾病的发生和发展中都起着重要作用。不同的情况，如病毒感染、脂肪性肝病、肝脏缺血再灌注以及药物性肝损伤，都伴有肝细胞凋亡。这篇综述总结了近期有关肝细胞凋亡机制的研究，涉及经典的外源性和内源性凋亡途径、内质网应激以及氧化应激诱导的凋亡。我们根据不同肝脏疾病的特点强调了凋亡的主要原因。还提出了关于未来研究和临床应用的一些关注点。
Hepatocyte apoptosis plays important roles in both the removal of external microorganisms and the occurrence and development of liver diseases. Different conditions, such as virus infection, fatty liver disease, hepatic ischemia reperfusion, and drug-induced liver injury, are accompanied by hepatocyte apoptosis. This review summarizes recent research on the mechanism of hepatocyte apoptosis involving the classical extrinsic and intrinsic apoptotic pathways, endoplasmic reticulum stress, and oxidative stress-induced apoptosis. We emphasized the major causes of apoptosis according to the characteristics of different liver diseases. Several concerns regarding future research and clinical application are also raised.