Integration of nutrient, energy, light, and hormone signalling via TOR in plants.
Integration of nutrient, energy, light, and hormone signalling via TOR in plants.
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DOI：
10.1093/jxb/erz028
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发表时间：
2019-02
影响因子：
6.9
通讯作者：
Yue Wu;Lin Shi;Lei Li;Liwen Fu;Yanlin Liu;Yan Xiong;J. Sheen
中科院分区：
文献类型：
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作者：
Yue Wu;Lin Shi;Lei Li;Liwen Fu;Yanlin Liu;Yan Xiong;J. Sheen
雷帕霉素(TOR)的多结构域靶点是一种非典型的丝氨酸/苏氨酸蛋白激酶，类似于磷脂酰肌醇脂蛋白激酶，但保留了高度的序列同源性，并在酵母、植物和人类中作为主要信号整合子发挥着非常保守的作用。Tor根据营养、能量、激素和环境提示，动态协调细胞代谢、生物发生、器官生长和发育转变。在这里，我们综述了关于TOR在转录组重新编程、幼苗、根和茎的生长以及糖和能量信号激活的根毛产生中的多功能和复杂作用的最新发现。我们探索了TOR介导的光和激素信号的协调如何参与根和地上部顶端分生组织的激活、叶原基的增殖、子叶/叶的绿化和下胚轴的伸长。我们还讨论了TOR在硫同化和代谢中的新功能，并考虑了TOR、糖、能量和其他必需的常量营养素之间潜在的分子联系和正反馈环。
The multidomain target of rapamycin (TOR) is an atypical serine/threonine protein kinase resembling phosphatidylinositol lipid kinases, but retains high sequence identity and serves a remarkably conserved role as a master signalling integrator in yeasts, plants, and humans. TOR dynamically orchestrates cell metabolism, biogenesis, organ growth, and development transitions in response to nutrient, energy, hormone, and environmental cues. Here we review recent findings on the versatile and complex roles of TOR in transcriptome reprogramming, seedling, root, and shoot growth, and root hair production activated by sugar and energy signalling. We explore how co-ordination of TOR-mediated light and hormone signalling is involved in root and shoot apical meristem activation, proliferation of leaf primordia, cotyledon/leaf greening, and hypocotyl elongation. We also discuss the emerging TOR functions in response to sulfur assimilation and metabolism and consider potential molecular links and positive feedback loops between TOR, sugar, energy, and other essential macronutrients.