Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
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DOI：
10.1007/s11010-010-0709-x
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发表时间：
2011-05-01
影响因子：
4.3
通讯作者：
Ahsan, Haseeb
中科院分区：
文献类型：
--
作者：
Ola, Mohammad Shamsul;Nawaz, Mohd;Ahsan, Haseeb
细胞凋亡，或程序性细胞死亡，在消除多细胞生物体中不需要的、受损的或感染的细胞以及包括发育、细胞分化和增殖在内的各种生物过程中发挥着关键作用。细胞凋亡是一种高度调控的细胞死亡形式，细胞凋亡的失调会导致包括癌症、自身免疫和神经退行性疾病在内的病理情况。Bcl2家族蛋白是细胞凋亡的关键调节蛋白，包括抗凋亡蛋白和促凋亡蛋白，这些蛋白的动态平衡的轻微变化可能导致抑制或促进细胞死亡。各种刺激通过激活内源或外源通路启动细胞凋亡，这些通路导致一系列下游事件的发生，线粒体释放各种凋亡介质，激活对细胞命运至关重要的半胱氨酸蛋白酶。鉴于近年来对细胞凋亡机制的研究进展，本文着重介绍了细胞凋亡的基本概念及其受Bcl2蛋白家族的调控。此外，本文还讨论了决定细胞命运的各种凋亡调节因子和半胱氨酸天冬氨酸蛋白酶的相互作用。我们期待这一综述将增加了解细胞凋亡机制所需的基本信息库，这可能有助于设计更好的策略来开发生物医学疗法来控制细胞凋亡。
Apoptosis, or programmed cell death, plays a pivotal role in the elimination of unwanted, damaged, or infected cells in multicellular organisms and also in diverse biological processes, including development, cell differentiation, and proliferation. Apoptosis is a highly regulated form of cell death, and dysregulation of apoptosis results in pathological conditions including cancer, autoimmune and neurodegenerative diseases. The Bcl-2 family proteins are key regulators of apoptosis, which include both anti- and pro-apoptotic proteins, and a slight change in the dynamic balance of these proteins may result either in inhibition or promotion of cell death. Execution of apoptosis by various stimuli is initiated by activating either intrinsic or extrinsic pathways which lead to a series of downstream cascade of events, releasing of various apoptotic mediators from mitochondria and activation of caspases, important for the cell fate. In view of recent research advances about underlying mechanism of apoptosis, this review highlights the basics concept of apoptosis and its regulation by Bcl-2 family of protein. Furthermore, this review discusses the interplay of various apoptotic mediators and caspases to decide the fate of the cell. We expect that this review will add to the pool of basic information necessary to understand the mechanism of apoptosis which may implicate in designing better strategy to develop biomedical therapy to control apoptosis.