DESICCATION, FLIGHT, GLYCOGEN, AND POSTPONED SENESCENCE IN DROSOPHILA-MELANOGASTER
DESICCATION, FLIGHT, GLYCOGEN, AND POSTPONED SENESCENCE IN DROSOPHILA-MELANOGASTER
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DOI：
10.1086/physzool.65.2.30158253
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发表时间：
1992-03-01
期刊：
影响因子：
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通讯作者：
ROSE, MR
中科院分区：
文献类型：
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作者：
GRAVES, JL;TOOLSON, EC;ROSE, MR
选择延缓衰老的果蝇对干燥的抵抗力增强，飞行时间延长。这些和其他人口进行了测试寿命，飞行时间，糖原含量，并在各种条件下的抗应激能力。结果表明，干燥抗性与飞行时间和糖原含量呈正相关，而糖原在干燥过程中耗尽，因为它是在飞行中。延缓衰老的苍蝇在死亡时也有较低的失水率（WLR），这表明糖原含量以外的因素是其抗干燥性增加的部分原因。然而，总表皮碳氢化合物似乎并不能决定抗干燥性。无论是选择还是操作，饥饿抗性都不会以与干燥抗性相对应的方式变化，但确实与脂质水平相关。这表明这些果蝇中至少有两种延缓衰老的生理机制：脂质含量增加和糖原含量增加。这些机制至少在某种程度上是独立的，在进化上，遗传上和生理上。
Drosophila melanogaster selected for postponed aging have increased resistance to desiccation and increased flight duration. These and other populations were tested for longevity, flight duration, glycogen content, and stress resistance under a variety of conditions. It was found that desiccation resistance was positively associated with flight duration and glycogen content, while glycogen was exhausted in the course of desiccation, as it is in flight. Flies with postponed aging also have lower water-loss rates (WLRs) when dead, suggesting that factors other than glycogen content are partly responsible for their increased desiccation resistance However, total epicuticular hydrocarbon does not appear to determine desiccation resistance. Starvation resistance does not vary in a manner that corresponds with desiccation resistance, under either selection or manipulation, but does vary in association with lipid level This suggests at least two physiological mechanisms by which aging has been postponed in these flies: increased lipid content and increased glycogen content. These mechanisms are at least somewhat independent, evolutionarily, genetically, and physiologically.