Effect of increased inspiratory muscle work on blood flow to inactive and active limbs during submaximal dynamic exercise
Effect of increased inspiratory muscle work on blood flow to inactive and active limbs during submaximal dynamic exercise
复制标题
次最大动态运动期间吸气肌做功增加对不活动和活动肢体血流的影响
DOI：
10.1113/ep087380
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发表时间：
2019
影响因子：
2.7
通讯作者：
Sheel A. William
中科院分区：
文献类型：
--
作者：
Katayama Keisho;Goto Kanako;Shimizu Kaori;Saito Mitsuru;Ishida Koji;Zhang Luyu;Shiozawa Kana;Sheel A. William
新发现本研究的中心问题是什么？呼吸肌激活增加通过呼吸肌代谢反射与神经和心血管后果相关。源于呼吸肌组织的交感神经血管收缩增加是否会导致流向非活动肢体的血流减少，以维持流向活动肢体的血流？主要发现及其重要性是什么？手臂血流量减少，而腿部血流量保存在轻度腿部运动与吸气阻力。当呼吸肌诱导的代谢反射被激活时，通过交感神经控制血流再分配来维持活动肢体的血流。AbstractThe目的是阐明增加吸气肌工作对不活动和活动肢体血流的影响。健康年轻男性（n= 10，20 ± 2岁）在40%峰值摄氧量下进行了两次双侧动态膝关节伸展和膝关节屈曲运动试验，持续10分钟。这些试验包括自主呼吸5分钟，然后进行自主过度通气5分钟，无论是否存在吸气阻力（40%的最大吸气口压，吸气占空比为50%，呼吸频率为40次/min）。使用手指光电体积描记法获得平均动脉血压。使用多普勒超声监测肱动脉（活动肢体）和股动脉（活动肢体）中的血流。运动时平均动脉压（121 ± 7 mmHg）显著高于无阻力时（99 ± 5 mmHg）（P< 0.05）。与静息水平相比，在无吸气阻力的情况下，运动期间肱动脉血流量增加（120 ± 31 ml min−1），而在有吸气阻力的情况下，肱动脉血流量则减弱（65 ± 43 ml min−1）。股动脉血流量在运动开始时增加，并在整个运动过程中保持不变，没有吸气阻力（2576 ± 640 ml min−1），当增加吸气阻力时无变化（2634 ± 659 ml min−1;P> 0.05）。这些结果表明，交感神经对血液重新分布到活动肢体的控制在一定程度上是由呼吸肌诱导的代谢反射促进的。
New FindingsWhat is the central question of this study?Increased respiratory muscle activation is associated with neural and cardiovascular consequences via the respiratory muscle metaboreflex. Does increased sympathetic vasoconstriction originating from the respiratory musculature elicit a reduction in blood flow to an inactive limb in order to maintain blood flow to an active limb?What is the main finding and its importance?Arm blood flow was reduced whereas leg blood flow was preserved during mild leg exercise with inspiratory resistance. Blood flow to the active limb is maintained via sympathetic control of blood flow redistribution when the respiratory muscle‐induced metaboreflex is activated.AbstractThe purpose of this study was to elucidate the effect of increasing inspiratory muscle work on blood flow to inactive and active limbs. Healthy young men (n= 10, 20 ± 2 years of age) performed two bilateral dynamic knee‐extension and knee‐flexion exercise tests at 40% peak oxygen uptake for 10 min. The trials consisted of spontaneous breathing for 5 min followed by voluntary hyperventilation either with or without inspiratory resistance for 5 min (40% of maximal inspiratory mouth pressure, inspiratory duty cycle of 50% and a breathing frequency of 40 breaths min−1). Mean arterial blood pressure was acquired using finger photoplethysmography. Blood flow in the brachial artery (inactive limb) and in the femoral artery (active limb) were monitored using Doppler ultrasound. Mean arterial blood pressure during exercise was higher (P< 0.05) with inspiratory resistance (121 ± 7 mmHg) than without resistance (99 ± 5 mmHg). Brachial artery blood flow increased during exercise without inspiratory resistance (120 ± 31 ml min−1) compared with the resting level, whereas it was attenuated with inspiratory resistance (65 ± 43 ml min−1). Femoral artery blood flow increased at the onset of exercise and was maintained throughout exercise without inspiratory resistance (2576 ± 640 ml min−1) and was unchanged when inspiratory resistance was added (2634 ± 659 ml min−1;P> 0.05). These results suggest that sympathetic control of blood redistribution to active limbs is facilitated, in part, by the respiratory muscle‐induced metaboreflex.