Prevalence of systemic lupus erythematosus in Spain: higher than previously reported in other countries?
Prevalence of systemic lupus erythematosus in Spain: higher than previously reported in other countries?
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DOI：
10.1093/rheumatology/kez668
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发表时间：
2020-09-01
期刊：
影响因子：
5.5
通讯作者：
Bustabad, Sagrario
中科院分区：
文献类型：
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作者：
Cortes Verdu, Raul;Pego-Reigosa, Jose M.;Bustabad, Sagrario
目标. SLE的患病率因研究设计、地理区域和种族而异。关于西班牙SLE患病率的数据很少。在EPISER 2016研究中，由西班牙风湿病学会推广，更新了西班牙一般成年人群中SLE的患病率估计值，并探讨了其与社会人口统计学，人体测量学和生活方式变量的相关性。以人群为基础的多中心横断面研究，采用多阶段分层和整群随机抽样。通过电话联系参与者进行SLE筛查问卷调查。研究风湿病学家评价阳性结果（审查病历和/或电话访谈，如需要进行医疗访视）以确认诊断。为了计算患病率及其95% CI，考虑了样本设计，并根据年龄、性别和地理来源计算了权重。采用多因素Logistic回归模型分析电话问卷中的社会人口学、人体测量学和生活方式变量与SLE的存在相关。纳入了4916例20岁或以上的受试者。SLE筛查阳性率为16.52%（812/4916）。检测SLE 12例。估计患病率为0.21%（95%CI：0.11，0.40）。SLE在农村地区的患病率较高，OR = 4.041（95%CI：1.216，13.424）。西班牙SLE的估计患病率高于大多数国际流行病学研究中的描述，但低于美国或英国少数民族中观察到的患病率。
Objectives. Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by the Spanish Society of Rheumatology, the prevalence estimate of SLE in the general adult population in Spain has been updated and its association with sociodemographic, anthropometric and lifestyle variables has been explored.Methods. Population-based multicentre cross-sectional study, with multistage stratified and cluster random sampling. Participants were contacted by telephone to carry out a questionnaire for the screening of SLE. Investigating rheumatologists evaluated positive results (review of medical records and/or telephone interview, with medical visit if needed) to confirm the diagnosis. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated considering age, sex and geographic origin. Multivariate logistic regression models were defined to analyse which sociodemographic, anthropometric and lifestyle variables included in the telephone questionnaire were associated with the presence of SLE.Results. 4916 subjects aged 20 years or over were included. 16.52% (812/4916) had a positive screening result for SLE. 12 cases of SLE were detected. The estimated prevalence was 0.21% (95% CI: 0.11, 0.40). SLE was more prevalent in the rural municipalities, with an odds ratio (OR) = 4.041 (95% CI: 1.216, 13.424).Conclusion. The estimated prevalence of SLE in Spain is higher than that described in most international epidemiological studies, but lower than that observed in ethnic minorities in the United States or the United Kingdom.