Cellular aging and telomere dynamics in pregnancy.
Cellular aging and telomere dynamics in pregnancy.
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DOI：
10.1097/gco.0000000000000765
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发表时间：
2022-04-01
影响因子：
2.1
通讯作者：
Bianco K
中科院分区：
文献类型：
--
作者：
Panelli DM;Bianco K
端粒生物学是一个新兴的科学领域。端粒是染色体末端的DNA帽，随着人的寿命自然缩短;正因为如此，短端粒已被研究为细胞衰老的标志。鉴于短端粒与遗传和环境因素之间的关联，它们在怀孕中的作用已成为一个有趣的研究领域。本文综述了最近的数据端粒在怀孕。具体而言，我们讨论了短母体白细胞端粒和营养状况差之间的关联，短新生儿端粒和更大的产妇心理社会压力之间的关联，以及短胎儿羊膜端粒和分娩的自发性发作之间的关联。我们还回顾了最近的研究，表明怀孕期间的事件可能会影响未来几年后代的端粒。端粒长度在母体、胎盘和新生儿细胞中各不相同，但在这些细胞中，端粒在妊娠期间可能发挥各自独特的作用。端粒是否反映了压力源的累积影响，或者是一个未知的胎儿编程机制的一部分，是一个感兴趣的领域。随着未来的研究，我们可能会努力更好地了解妊娠生物学，这可能会产生深远的代际影响。
Telomere biology is an emerging area of scientific interest. Telomeres are DNA caps at the ends of chromosomes that naturally shorten over one’s lifespan; because of this, short telomeres have been studied as a marker of cellular aging. Given the association between short telomeres and genetic and environmental factors, their role in pregnancy has become an intriguing area of research. This review describes recent data on telomeres in pregnancy. Specifically, we discuss the association between short maternal leukocyte telomeres and poor nutritional status, between short neonatal telomeres and greater maternal psychosocial stress, and between shorter fetal amniotic membrane telomeres and the spontaneous onset of parturition. We also review recent studies suggesting that events during pregnancy can impact telomeres in the offspring years into the future. Telomere length varies in maternal, placental, and neonatal cells, but within each of these compartments telomeres may play their own distinct role during pregnancy. Whether telomeres are reflective of the cumulative impact of stressors, or part of an as-yet unknown fetal programming mechanism is an area of interest. With future research, we may work towards a better understanding of gestational biology which could have far reaching intergenerational impacts.