Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases.
Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases.
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DOI：
10.1098/rstb.2012.0267
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发表时间：
2013-07-19
期刊：
影响因子：
--
通讯作者：
Wallace DC
中科院分区：
文献类型：
--
作者：
Wallace DC
目前的新达尔文进化论认为，自然选择作用下的随机染色体突变产生新物种，这一理论存在两个主要的矛盾之处。首先，自然选择不需要不断增加复杂性的进化，但这是生物学的特征。第二，人类染色体DNA序列变异主要是中性或有害的，不足以提供物种形成或对常见疾病的偏好所需的变异。生物圈中持续不断的能量流驱动着核酸和信息的积累，这解释了复杂性。然后信息编码复杂的形式。在动物中，能量流动主要由线粒体介导，线粒体的母系遗传线粒体DNA （mtDNA）编码能量代谢的关键基因。在哺乳动物中，mtDNA具有非常高的突变率，但有害的突变被卵巢选择系统去除。因此，微妙地改变能量代谢的新突变不断被引入物种，使其能够适应能量环境的区域差异。因此，最显着的基因变异出现在mtDNA中，是区域性的，并允许动物占据外围能量环境，在那里更罕见的核DNA （nDNA）变异可以积累，导致物种形成。中性主义者和选择主义者之间的争论是哺乳动物有两种不同进化策略的结果：一种快速的mtDNA策略用于特异性内辐射，一种缓慢的nDNA策略用于物种形成。此外，人类常见疾病缺失的遗传变异主要是mtDNA变异和区域nDNA变异，这两种变异在大型种群间关联研究中都被遗漏了。
Two major inconsistencies exist in the current neo-Darwinian evolutionary theory that random chromosomal mutations acted on by natural selection generate new species. First, natural selection does not require the evolution of ever increasing complexity, yet this is the hallmark of biology. Second, human chromosomal DNA sequence variation is predominantly either neutral or deleterious and is insufficient to provide the variation required for speciation or for predilection to common diseases. Complexity is explained by the continuous flow of energy through the biosphere that drives the accumulation of nucleic acids and information. Information then encodes complex forms. In animals, energy flow is primarily mediated by mitochondria whose maternally inherited mitochondrial DNA (mtDNA) codes for key genes for energy metabolism. In mammals, the mtDNA has a very high mutation rate, but the deleterious mutations are removed by an ovarian selection system. Hence, new mutations that subtly alter energy metabolism are continuously introduced into the species, permitting adaptation to regional differences in energy environments. Therefore, the most phenotypically significant gene variants arise in the mtDNA, are regional, and permit animals to occupy peripheral energy environments where rarer nuclear DNA (nDNA) variants can accumulate, leading to speciation. The neutralist–selectionist debate is then a consequence of mammals having two different evolutionary strategies: a fast mtDNA strategy for intra-specific radiation and a slow nDNA strategy for speciation. Furthermore, the missing genetic variation for common human diseases is primarily mtDNA variation plus regional nDNA variants, both of which have been missed by large, inter-population association studies.
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影响因子：
56.9
作者：
Fan, Weiwei;Waymire, Katrina G.;Wallace, Douglas C.
通讯作者：
Wallace, Douglas C.
DOI：
10.1098/rspb.2009.0752
发表时间：
2009-10-07
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Balloux F;Handley LJ;Jombart T;Liu H;Manica A
通讯作者：
Manica A
线粒体DNA多态性的鉴定会改变线粒体基质pH和细胞内钙动力学。
影响因子：
4.5
作者：
Kazuno, An-a;Munakata, Kae;Nagai, Takeharu;Shimozono, Satoshi;Tanaka, Masashi;Yoneda, Makoto;Kato, Nobumasa;Miyawaki, Atsushi;Kato, Tadafumi
通讯作者：
Kato, Tadafumi
影响因子：
3.9
作者：
BROWN, MD;TORRONI, A;WALLACE, DC
通讯作者：
WALLACE, DC
影响因子：
64.8
作者：
CANN, RL;STONEKING, M;WILSON, AC
通讯作者：
WILSON, AC