Genome wide expression profiling of angiogenic signaling and the Heisenberg uncertainty principle
Genome wide expression profiling of angiogenic signaling and the Heisenberg uncertainty principle
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DOI：
10.4161/cc.3.11.1209
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发表时间：
2004-11-01
期刊：
影响因子：
4.3
通讯作者：
Abdollahi, A
中科院分区：
文献类型：
--
作者：
Huber, PE;Hauser, K;Abdollahi, A
基因组范围内的DNA表达谱结合抗体阵列实验，利用内皮抑素探测人内皮细胞血管生成信号网络。结果揭示了测量过程中的约束，这与维尔纳·海森堡描述的量子力学的不确定性原理所隐含的约束类似。我们描述了这种类比，并为其启发式效用的概念血管生成作为肿瘤形成的一个重要步骤。
Genome wide DNA expression profiling coupled with antibody array experiments using endostatin to probe the angiogenic signaling network in human endothelial cells were performed. The results reveal constraints on the measuring process that are of a similar kind as those implied by the uncertainty principle of quantum mechanics as described by Werner Heisenberg. We describe this analogy and argue for its heuristic utility in the conceptualization of angiogenesis as an important step in tumor formation.