Maternal triglyceride levels and newborn weight in pregnant women with normal glucose tolerance
Maternal triglyceride levels and newborn weight in pregnant women with normal glucose tolerance
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DOI：
10.1111/j.1464-5491.2004.01336.x
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发表时间：
2005-01-01
影响因子：
3.5
通讯作者：
Del Prato, S
中科院分区：
文献类型：
--
作者：
Di Cianni, G;Miccoli, R;Del Prato, S
目的探讨糖尿病筛查阳性但糖耐量正常的孕妇血清甘油三酯（TG）水平对新生儿体重的预测价值。所有妇女在妊娠第27 +/-4周时进行3小时100 g口服葡萄糖耐量试验（OGTT）。在OGTT时检测空腹血糖、空腹血脂，并检测ApoE基因多态性，以评价其对血脂水平的影响。在83名妇女与正常的葡萄糖耐量和足月分娩，我们评估了产妇血清甘油三酯，特定的母体参数已知影响胎儿生长和新生儿weight.Results之间的关联，诊断为妊娠期糖尿病（GDM）36名妇女（20%），糖耐量受损（IGT）23（13%），和正常的葡萄糖耐量（NGT）在121（67%）。GDM组血清TG浓度（2.47 ± 0.77 mmol/l）显著高于NGT组（1.99 ± 0.64 mmol/l）和IGT组（1.98 ± 0.81 mmol/l）（P
Objective To determine the predictive value of serum triglyceride levels (TG) for neonatal weight in pregnant women with positive diabetic screening but normal glucose tolerance.Research design and methods We enrolled 180 pregnant Caucasian women with positive diabetic screening. All women underwent a 3-h 100-g oral glucose tolerance test (OGTT) at 27th+/-4 week of gestation. At the time of OGTT, we measured: fasting plasma glucose, fasting lipids profile and determined ApoE polymorphisms to evaluate the effects on lipid levels. In 83 women with normal glucose tolerance and at term delivery we evaluated the association between maternal serum TG, specific maternal parameters known to affect fetal growth and newborn weight.Results Based on OGTT, gestational diabetes mellitus (GDM) was diagnosed in 36 women (20%), impaired glucose tolerance (IGT) in 23 (13%), and normal glucose tolerance (NGT) in 121 (67%). Serum TG concentration was significantly higher in women with GDM (2.47+/-0.77 mmol/l) as compared with NGT (1.99+/-0.64 mmol/l) or IGT (1.98+/-0.81 mmol/l) (P