Curcumin effects on blood lipid profile in a 6-month human study
Curcumin effects on blood lipid profile in a 6-month human study
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DOI：
10.1016/j.phrs.2007.09.013
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发表时间：
2007-12-01
影响因子：
9.3
通讯作者：
Lam, Christopher W. K.
中科院分区：
文献类型：
--
作者：
Baum, Larry;Cheung, Stanley K. K.;Lam, Christopher W. K.
动物研究和短期人体研究表明，姜黄素，一种浓缩在咖喱香料姜黄中的多酚化合物，降低血清胆固醇浓度。然而，没有对照人体试验研究姜黄素对胆固醇的影响。这项研究调查了食用姜黄素对男性和女性血脂谱的影响。老年受试者（n=36）在6个月的随机双盲试验中消耗4g/d姜黄素，1g/d姜黄素或安慰剂。在1个月时测量血浆姜黄素及其代谢产物，并在基线、1个月和6个月时测量血脂谱。血浆姜黄素浓度达到平均490 nmol/L。胶囊给药后姜黄素浓度高于粉末给药后。在1个月或6个月内，食用任何剂量的姜黄素都不会显著影响三酰甘油，或总胆固醇，LDL和HDL胆固醇。而血浆姜黄素浓度与血清胆固醇浓度呈显著正相关。姜黄素的消耗似乎对血脂谱没有显着影响，除非考虑姜黄素的吸收浓度，在这种情况下，姜黄素可能会适度增加胆固醇。(c)2007爱思唯尔有限公司保留所有权利。
Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects (n=36) consumed 4g/d curcumin, 1 g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol. (c) 2007 Elsevier Ltd. All rights reserved.