Deficits in sequential processing manifest in motor and linguistic tasks in a multigenerational family with childhood apraxia of speech
Deficits in sequential processing manifest in motor and linguistic tasks in a multigenerational family with childhood apraxia of speech
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DOI：
10.3109/02699206.2012.736011
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发表时间：
2013-03-01
影响因子：
1.2
通讯作者：
Raskind, Wendy H.
中科院分区：
文献类型：
--
作者：
Peter, Beate;Button, Le;Raskind, Wendy H.
本研究的目的是评估患有家族性儿童言语失用症 (CAS) 的家庭中作为候选内表型的顺序处理的整体缺陷。在一个患有符合 CAS 的言语声音障碍 (SSD) 的三代家庭中，有 10 名成人和 13 名儿童，其中 3 名成人和 6 名儿童过去或现在患有 SSD 诊断。两名未接受 CAS 治疗的学龄前儿童在单字生成过程中出现大量测序错误。受影响和未受影响的家庭成员在高顺序处理负载任务上的表现存在差异，而在低处理负载任务上则没有组间差异。与没有 SSD 病史的成年人相比，有 SSD 病史的成年人在非单词和多音节真实单词模仿中产生更多的排序错误。结果与影响言语发展以及认知和语言处理的顺序处理的整体缺陷一致。
The purpose of this study was to evaluate a global deficit in sequential processing as candidate endophenotypein a family with familial childhood apraxia of speech (CAS). Of 10 adults and 13 children in a three-generational family with speech sound disorder (SSD) consistent with CAS, 3 adults and 6 children had past or present SSD diagnoses. Two preschoolers with unremediated CAS showed a high number of sequencing errors during single-word production. Performance on tasks with high sequential processing loads differentiated between the affected and unaffected family members, whereas there were no group differences in tasks with low processing loads. Adults with a history of SSD produced more sequencing errors during nonword and multisyllabic real word imitation, compared to those without such a history. Results are consistent with a global deficit in sequential processing that influences speech development as well as cognitive and linguistic processing.