NECROTIZING ENTEROCOLITIS - ROLE OF PLATELET ACTIVATING FACTOR, ENDOTOXIN, AND TUMOR-NECROSIS-FACTOR
NECROTIZING ENTEROCOLITIS - ROLE OF PLATELET ACTIVATING FACTOR, ENDOTOXIN, AND TUMOR-NECROSIS-FACTOR
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DOI：
10.1016/s0022-3476(05)81130-8
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发表时间：
1990-07-01
影响因子：
5.1
通讯作者：
HSUEH, W
中科院分区：
文献类型：
--
作者：
CAPLAN, MS;HSUEH, W
虽然坏死性小肠结肠炎的许多危险因素已被描述，病理生理仍然知之甚少。我们开发了一种缺血性肠坏死的大鼠模型，类似于人类新生儿NEC，通过注射血小板活化因子到内脏循环。本文综述了PAF在休克和肠损伤中的作用，讨论了可能与PAF相互作用并导致肠道异常的其他介质，并提出了PAF与人类NEC相关的证据。
Although many risk factors for necrotizing enterocolitis have been described, the pathophysiology remains poorly understood. We developed a model of ischemic bowel necrosis in the rat, similar to human neonatal NEC, by injecting platelet activating factor into the splanchnic circulation. In this review, we describe the role of PAF in shock and bowel injury, discuss some other mediators that may interact with PAF and contribute to the intestinal abnormality, and present evidence associating PAF and human NEC.