The dynamic spatial and temporal relationships between the phalanx-forming region and the interdigits determine digit identity in the chick limb autopod.
The dynamic spatial and temporal relationships between the phalanx-forming region and the interdigits determine digit identity in the chick limb autopod.
复制标题
指骨形成区域和指间之间的动态空间和时间关系决定了雏鸡肢体自动足中的数字身份。
DOI：
10.1002/dvdy.323
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Fallon,JohnF
中科院分区：
文献类型：
--
作者：
Suzuki,Takayuki;Fallon,JohnF
背景鸡肢指间（Interdigits，ID）决定着鸡肢指的同一性.它们位于数字射线之间，并作为音刺猬下游的二级信号中心，为确定指骨形成区域（PFR）中的数字身份提供位置信息。我们研究的动态发展机制，PFR细胞获得的位置信息，从ID，以确定在鸡hindlimb.ResultsWe个别数字的身份，确定负责数字身份的ID的特定区域，并表明，PFR细胞积极接收位置信息只从后方，而不是前方，位于ID。我们还证明了数字1、2和3可以相互互换，但不能与数字4互换。最后，我们发现，ID4和数字射线4是必要的，以确定数字4 identity.ConclusionsThe数字射线是天真的，在其发展的初始阶段，在这个时候数字身份不确定。为了确定数字身份，每个PFR单元示出了单向响应，以具体地从位于PFR后面的ID获得位置信息，而不管来自位于前面的ID的信号强度如何。
BackgroundInterdigits (IDs) determine digit identity in chick limbs. They are located between the digital rays and act as secondary signaling centers downstream of sonic hedgehog to provide positional information for determining digit identity in the phalanx‐forming region (PFR). We examined the dynamic developmental mechanism by which PFR cells obtain positional information from IDs to determine the identity of individual digits in the chick hindlimb.ResultsWe identified the specific region of the IDs responsible for determining digit identity and showed that PFR cells actively receive positional information only from the posteriorly, and not the anteriorly, located IDs. We also demonstrated that digits 1, 2, and 3 are interchangeable with each other, but not with digit 4. Finally, we found that both ID4 and digital ray 4 are necessary for determining digit 4 identity.ConclusionsThe digital rays are naïve during the initial stages of their development, at which time digit identity is not determined. To determine digit identity, each PFR cell shows a unidirectional response to obtain positional information specifically from the IDs located posterior to the PFR, regardless of the signal strength from the anteriorly located IDs.